N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury

doi:10.3748/wjg.v20.i41.15289

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Nov 7, 2014 (publication date) through Apr 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Nov 7, 2014; 20(41): 15289-15298
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15289

N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury

Yong Sun, Li-Yong Pu, Ling Lu, Xue-Hao Wang, Feng Zhang, Jian-Hua Rao

Yong Sun, Department of General Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu Province, China

Yong Sun, Li-Yong Pu, Ling Lu, Xue-Hao Wang, Feng Zhang, Jian-Hua Rao, Key Laboratory of Living Donor Liver Transplantation of Chinese Ministry of Health, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

Author contributions: Sun Y and Pu LY contributed equally to this work; Sun Y, Pu LY, Zhang F and Rao JH contributed to conception and design; Sun Y, Lu L and Rao JH contributed to the data analysis and interpretation; Sun Y, Pu LY and Rao JH contributed to the data collection; Lu L, Wang XH and Rao JH contributed to the manuscript preparation; Sun Y, Lu L, Zhang F and Rao JH contributed to the critical revision of the article.

Supported by First Affiliated Hospital of Nanjing Medical University and the National Natural Science Foundation of China, Grant No. 81100270, No. 81070380, No. 81310108001, No. 81210108017 and No.81273261

Correspondence to: Feng Zhang, MD, PhD, Key Laboratory of Living Donor Liver Transplantation of Chinese Ministry of Health, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. zhangf@njmu.edu.cn

Telephone: +86-25-83718836 Fax: +86-25-83672106

Received: February 11, 2013
Revised: April 8, 2014
Accepted: June 26, 2014
Published online: November 7, 2014

Core Tip

Core tip: The protective effect of N-acetylcysteine (NAC) treatment has been confirmed in IRI; however, its underlying mechanism remains unclear. Our previous data showed that endoplasmic reticulum (ER) stress is critical for the development of liver IRI. We have found new evidence for the protective effects of NAC on hepatocytes during liver IRI. Our data demonstrated that NAC modulates ER stress signaling and reduces ER-stress-mediated apoptosis during liver IRI. These findings provide further support for the usefulness of exploring NAC as a potential alternative drug for treating liver IRI.