Case Control Study
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World J Gastroenterol. Nov 7, 2014; 20(41): 15343-15350
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15343
Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies
Gabor Lendvai, Katalin Jármay, Gizella Karácsony, Tünde Halász, Ilona Kovalszky, Kornélia Baghy, Tibor Wittmann, Zsuzsa Schaff, András Kiss
Gabor Lendvai, Zsuzsa Schaff, MTA-SE Tumor Progression Research Group, Semmelweis University, 1091 Budapest, Hungary
Katalin Jármay, Gizella Karácsony, Tibor Wittmann, 1st Department of Medicine, University of Szeged, 6720 Szeged, Hungary
Tünde Halász, Zsuzsa Schaff, András Kiss, 2nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary
Ilona Kovalszky, Kornélia Baghy, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary
Author contributions: Jármay K, Schaff Z and Kiss A designed the study; Jármay K, Karácsony G, Kovalszky I, Wittmann T, Schaff Z and Kiss A chose and diagnosed the patient samples; Lendvai G, Karácsony G and Halász T performed the research; Lendvai G, Jármay K, Karácsony G, Kovalszky I, Baghy K, Schaff Z and Kiss A analyzed and interpreted the data; Lendvai G, Schaff Z and Kiss A wrote the paper; all authors critically reviewed and approved the manuscript.
Supported by Grants from the National Scientific Research Fund, No. OTKA K101435, No. K108548 and No. 105763
Correspondence to: Zsuzsa Schaff, MD, PhD, DSc, Professor of Pathology, 2nd Department of Pathology, Semmelweis University, Ulloi 93, 1091 Budapest, Hungary.
Telephone: +36-1-215-6921 Fax: +36-1-215-6921
Received: February 11, 2014
Revised: May 7, 2014
Accepted: June 13, 2014
Published online: November 7, 2014
Core Tip

Core tip: Chronic hepatitis C (CHC) and steatosis are liver diseases that can progress into hepatocellular carcinoma. In the current study, differences were found in expression of selected microRNAs in biopsy samples of steatotic liver, CHC-infected, and steatotic CHC-infected liver, compared to control samples. Interestingly, levels of miR-224, which are increased in hepatocellular carcinoma, were elevated in both types of steatotic liver when compared with normal or CHC-infected only liver tissues, and may be an indicator of a precancerous state.