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Topic Highlight
Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance 
Konstantinos A Paschos, Ali W Majeed, Nigel C Bird 
World J Gastroenterol 20(14):3719-3737. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3719
Colorectal cancer and immunity: What we know and perspectives 
Simon Pernot, Magali Terme, Thibault Voron, Orianne Colussi, Elie Marcheteau, Eric Tartour, Julien Taieb 
World J Gastroenterol 20(14):3738-3750. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3738
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation 
Chun Seng Lee, Elizabeth J Ryan, Glen A Doherty 
World J Gastroenterol 20(14):3751-3761. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3751
Personalized surgical management of colorectal cancer in elderly population 
Giampaolo Ugolini, Federico Ghignone, Davide Zattoni, Giacomo Veronese, Isacco Montroni 
World J Gastroenterol 20(14):3762-3777. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3762
Inhibition of host immune response in colorectal cancer: Human leukocyte antigen-G and beyond 
Marica Garziera, Giuseppe Toffoli 
World J Gastroenterol 20(14):3778-3794. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3778
Role of preoperative CT colonography in patients with colorectal cancer 
Lapo Sali, Massimo Falchini, Antonio Taddei, Mario Mascalchi 
World J Gastroenterol 20(14):3795-3803. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3795
Proteomics for discovery of candidate colorectal cancer biomarkers 
Paula Álvarez-Chaver, Olalla Otero-Estévez, María Páez de la Cadena, Francisco J Rodríguez-Berrocal, Vicenta S Martínez-Zorzano 
World J Gastroenterol 20(14):3804-3824. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3804
Colorectal cancer screening: 20 years of development and recent progress 
Miroslav Zavoral, Stepan Suchanek, Ondrej Majek, Premysl Fric, Petra Minarikova, Marek Minarik, Bohumil Seifert, Ladislav Dusek 
World J Gastroenterol 20(14):3825-3834. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3825
Chemopreventive drugs: Mechanisms via inhibition of cancer stem cells in colorectal cancer 
Tae Il Kim 
World J Gastroenterol 20(14):3835-3846. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3835
Current and future molecular diagnostics in colorectal cancer and colorectal adenoma 
Andy Hin-Fung Tsang, Ka-Ho Cheng, Apple Siu-Ping Wong, Simon Siu-Man Ng, Brigette Buig-Yue Ma, Charles Ming-Lok Chan, Nancy Bo-Yin Tsui, Lawrence Wing-Chi Chan, Benjamin Yat-Ming Yung, Sze-Chuen Cesar Wong 
World J Gastroenterol 20(14):3847-3857. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3847
Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer 
Hui-Yan Luo, Rui-Hua Xu 
World J Gastroenterol 20(14):3858-3874. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3858
Gastric cancer in Africa: Current management and outcomes 
Akwi W Asombang, Rubayat Rahman, Jamal A Ibdah 
World J Gastroenterol 20(14):3875-3879. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3875
Current role of minimally invasive approaches in the treatment of early gastric cancer 
Abraham El-Sedfy, Savtaj S Brar, Natalie G Coburn 
World J Gastroenterol 20(14):3880-3888. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3880
Extent of lymphadenectomy and perioperative therapies: Two open issues in gastric cancer 
Andrea Giuliani, Michelangelo Miccini, Luigi Basso 
World J Gastroenterol 20(14):3889-3904. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3889
Treatment options in patients with metastatic gastric cancer: Current status and future perspectives 
Ahmet Bilici 
World J Gastroenterol 20(14):3905-3915. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3905
DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus 
Keisuke Matsusaka, Sayaka Funata, Masashi Fukayama, Atsushi Kaneda 
World J Gastroenterol 20(14):3916-3926. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3916
An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa 
Hiroyuki Yamamoto, Yoshiyuki Watanabe, Tadateru Maehata, Ryo Morita, Yoshihito Yoshida, Ritsuko Oikawa, Shinya Ishigooka, Shun-ichiro Ozawa, Yasumasa Matsuo, Kosuke Hosoya, Masaki Yamashita, Hiroaki Taniguchi, Katsuhiko Nosho, Hiromu Suzuki, Hiroshi Yasuda, Yasuhisa Shinomura, Fumio Itoh 
World J Gastroenterol 20(14):3927-3937. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3927
Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: Do we have enough data to support this? 
Choong Nam Shim, Sang Kil Lee 
World J Gastroenterol 20(14):3938-3949. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3938
Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression 
Hsin-Chen Lee, Kuo-Hung Huang, Tien-Shun Yeh, Chin-Wen Chi 
World J Gastroenterol 20(14):3950-3959. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3950
New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer 
Lin-Hai Yan, Wei-Yuan Wei, Yu-Bo Xie, Qiang Xiao 
World J Gastroenterol 20(14):3960-3966. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3960
Clinical significance of lymph node metastasis in gastric cancer 
Jing-Yu Deng, Han Liang 
World J Gastroenterol 20(14):3967-3975. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3967
Post-infectious irritable bowel syndrome: Mechanistic insights into chronic disturbances following enteric infection 
Jennifer K Beatty, Amol Bhargava, Andre G Buret 
World J Gastroenterol 20(14):3976-3985. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3976
Original Article
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation 
Bjarte Fosby, Sigrid Næss, Johannes R Hov, James Traherne, Kirsten M Boberg, John Trowsdale, Aksel Foss, Pål-Dag Line, Andre Franke, Espen Melum, Helge Scott, Tom H Karlsen 
World J Gastroenterol 20(14):3986-4000. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3986
Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma 
Guo-Gui Sun, Ya-Di Wang, Da-Wei Cui, Yun-Jie Cheng, Wan-Ning Hu 
World J Gastroenterol 20(14):4001-4010. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4001
Research Report
Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens 
Stephen J Hayes, Keng Ngee Hng, Peter Clark, Fiona Thistlethwaite, Robert E Hawkins, Yeng Ang 
World J Gastroenterol 20(14):4011-4016. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4011
Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors 
Valentin Becker, Stefan Grotz, Christoph Schlag, Simon Nennstiel, Analena Beitz, Bernhard Haller, Roland M Schmid, Alexander Meining, Monther Bajbouj 
World J Gastroenterol 20(14):4017-4024. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4017
Non-small-bowel abnormalities identified during small bowel capsule endoscopy 
Reinier A Hoedemaker, Jessie Westerhof, Rinse K Weersma, Jan J Koornstra 
World J Gastroenterol 20(14):4025-4029. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4025
Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm 
Gianpaolo Balzano, Michele Carvello, Lorenzo Piemonti, Rita Nano, Riccardo Ariotti, Alessia Mercalli, Raffaella Melzi, Paola Maffi, Marco Braga, Carlo Staudacher 
World J Gastroenterol 20(14):4030-4036. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4030
Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland 
Imre Ilves, Anne Fagerström, Karl-Heinz Herzig, Petri Juvonen, Pekka Miettinen, Hannu Paajanen 
World J Gastroenterol 20(14):4037-4042. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4037
Acute right lower abdominal pain in women of reproductive age: Clinical clues 
Sinan Hatipoglu, Filiz Hatipoglu, Ruslan Abdullayev 
World J Gastroenterol 20(14):4043-4049. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4043
Clinical study using novel endoscopic system for measuring size of gastrointestinal lesion 
Kiyoshi Oka, Takeshi Seki, Tomohiro Akatsu, Takao Wakabayashi, Kazuo Inui, Junji Yoshino 
World J Gastroenterol 20(14):4050-4058. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4050
Single hepatocellular carcinoma ≤ 3 cm in left lateral segment: Liver resection or radiofrequency ablation? 
Jong Man Kim, Tae Wook Kang, Choon Hyuck David Kwon, Jae-Won Joh, Justin Sangwook Ko, Jae Berm Park, Hyunchul Rhim, Joon Hyeok Lee, Sung Joo Kim, Seung Woon Paik 
World J Gastroenterol 20(14):4059-4065. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4059
YouTube as a source of patient information on gallstone disease 
Jun Suh Lee, Ho Seok Seo, Tae Ho Hong 
World J Gastroenterol 20(14):4066-4070. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4066
Efficacy and tolerability of low-dose interferon-α in hemodialysis patients with chronic hepatitis C virus infection 
Kai-Li Wang, Han-Qian Xing, Hong Zhao, Jun-Wei Liu, Deng-Lian Gao, Xue-Hua Zhang, Hong-Yu Yao, Li Yan, Jun Zhao 
World J Gastroenterol 20(14):4071-4075. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4071
Evidence-Based Medicine
Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma 
Xiao-Qing Yang, Yun-Fei Xu, Sen Guo, Yi Liu, Shang-Lei Ning, Xiao-Fei Lu, Hui Yang, Yu-Xin Chen 
World J Gastroenterol 20(14):4076-4084. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4076
Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer 
Yun-Feng Wang, Fei-Ling Feng, Xu-Hong Zhao, Zhen-Xiong Ye, He-Ping Zeng, Zhen Li, Xiao-Qing Jiang, Zhi-Hai Peng 
World J Gastroenterol 20(14):4085-4092. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4085
Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review and meta-analysis 
Abhishek Choudhary, Jessica Winn, Sameer Siddique, Murtaza Arif, Zainab Arif, Ghassan M Hammoud, Srinivas R Puli, Jamal A Ibdah, Matthew L Bechtold 
World J Gastroenterol 20(14):4093-4101. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4093
Case Report
Simultaneous liver mucinous cystic and intraductal papillary mucinous neoplasms of the bile duct: A case report 
Agnieszka Budzynska, Marek Hartleb, Ewa Nowakowska-Dulawa, Robert Krol, Piotr Remiszewski, Michal Mazurkiewicz 
World J Gastroenterol 20(14):4102-4105. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4102
Primary rectal squamous cell carcinoma treated with surgery and radiotherapy 
Jun-Feng Wang, Zhen-Xing Wang, Xiao-Xiao Xu, Cui Wang, Jian-Zhong Liu 
World J Gastroenterol 20(14):4106-4109. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4106
Prolonged small vessel vasculitis with colon mucosal inflammation as first manifestations of Behçet’s disease 
Xiao-Ning Yang, Zhen-Shi Ye, Yan-Yun Fan, Yi-Qun Hu 
World J Gastroenterol 20(14):4110-4114. Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4110