Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

doi:10.3748/wjg.v20.i14.4085

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Gastroenterol. Apr 14, 2014; 20(14): 4085-4092
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4085

Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

Yun-Feng Wang, Fei-Ling Feng, Xu-Hong Zhao, Zhen-Xiong Ye, He-Ping Zeng, Zhen Li, Xiao-Qing Jiang, Zhi-Hai Peng

Yun-Feng Wang, Zhi-Hai Peng, Department of Hepatobiliary Surgery, Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China

Yun-Feng Wang, Zhen-Xiong Ye, He-Ping Zeng, Zhen Li, Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China

Fei-Ling Feng, Xiao-Qing Jiang, The First Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University, Shanghai 200438, China

Xu-Hong Zhao, Central Experiment Laboratory, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China

Author contributions: Wang YF and Peng ZH conceived the study and drafted the manuscript; Feng FL, Zhao XH, and Ye ZX performed chart review and follow-up of the study; Zeng HP, Li Z, and Jiang XQ helped to draft the manuscript and perform statistical analyses; Wang YF was responsible for the whole study; all authors read and approved the final manuscript.

Correspondence to: Yun-Feng Wang, PhD, Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, No. 450, Teng Yue Road, Shanghai 200090, China. wangyunfeng197911@163.com

Telephone: +86-21-65690520 Fax: +86-21-65696249

Received: December 26, 2013
Revised: January 23, 2014
Accepted: March 6, 2014
Published online: April 14, 2014

Core Tip

Core tip: Detection of serum tumor markers is simple, and has become a common clinical method for tumor screening. However, when these markers are used individually for the diagnosis of gallbladder cancer, inconsistent results have been obtained. The results of the present study suggest that combined detection of serum cancer antigens cancer antigens (CA)125, CA199, and CA242 can increase the specificity of gallbladder cancer (GBC) diagnosis. CA242 could be regarded as a tumor marker of GBC infiltration in the early stage. Multivariate survival analysis showed that cancer of the gallbladder neck and CA199 expression levels were independent prognostic factors.