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World J Gastroenterol. Apr 14, 2014; 20(14): 3960-3966
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3960
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3960
New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer
Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Yu-Bo Xie, Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Xiao Q and Xie YB conceived and designed this review; Xiao Q and Xie YB contributed equally to this work; Wei WY performed the literature search; Yan LH and Wei WY analyzed the data; Yan LH and Wei WY wrote the paper; Yan LH and Wei WY are equal contributors.
Supported by The National Natural Science Foundation of China, No. 81060201; Natural Science Foundation of Guangxi Zhuang Autonomous Region of China, No. 2011GXNSFA018273 and No. 2013GXNSFAA019163; and the Key Health Science Fund of Guangxi Zhuang Autonomous Region of China, No. 1298003-2-6
Correspondence to: Qiang Xiao, MD, PhD, Department of Surgery, the First Affiliated Hospital of Guangxi Medical University, No. 22, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Telephone: +86-771-5358325 Fax: +86-771-5358325
Received: September 26, 2013
Revised: December 22, 2013
Accepted: February 20, 2014
Published online: April 14, 2014
Revised: December 22, 2013
Accepted: February 20, 2014
Published online: April 14, 2014
Core Tip
Core tip: This review elucidates the relationship between caudal-related homeobox transcription factor 2 (CDX2) and gastric carcinoma, and promotes research to establish whether CDX2 induces drug resistance in gastric cancer. The review highlights that CDX2-positive expression should be a useful maker for diagnosis for patients with intestinal-phenotype gastric cancer, because of this useful maker, future drug and gene therapy targets in gastric cancer might be influenced.