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World J Gastroenterol. Apr 14, 2014; 20(14): 3738-3750
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3738
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3738
Colorectal cancer and immunity: What we know and perspectives
Simon Pernot, Orianne Colussi, Julien Taieb, Service d’Hépatogastro-entérologie et d’oncologie digestive, Hôpital Européen Georges-Pompidou, Université Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France
Magali Terme, Thibault Voron, Elie Marcheteau, Eric Tartour, Julien Taieb, INSERM U970, Paris Cardiovascular Research Center, Université Paris-Descartes, 75006 Paris, France
Eric Tartour, Service d’Immunologie biologique, Hôpital Européen Georges-Pompidou, Université Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France
Author contributions: Pernot S and Terme M wrote the paper; Pernot S, Terme M, Voron T, Colussi O, Marcheteau E, Tartour E and Taieb J helped conduct the literature review, analyze and discuss the litterature review and implications and commented on the manuscript at all stages.
Correspondence to: Dr. Julien Taieb, Service d’Hépatogastro-entérologie et d’oncologie digestive, Hôpital Européen Georges-Pompidou, Université Paris Descartes, Sorbonne Paris Cité 20, rue Leblanc, 75015 Paris, France. julien.taieb@egp.aphp.fr
Telephone: +33-1-56095042 Fax: +33-1-53987952
Received: October 31, 2013
Revised: January 8, 2014
Accepted: January 20, 2014
Published online: April 14, 2014
Revised: January 8, 2014
Accepted: January 20, 2014
Published online: April 14, 2014
Core Tip
Core tip: Immune system is now widely accepted as a key mechanism to prevent occurrence of cancer and intratumoral T CD8+ and CD45+ lymphocytes infiltrate has shown to be a major prognosis factor in colorectal cancer. However, immunity fail in controlling tumor growth, because of strong escape mechanisms to the immune system developed by the tumor. In recent years, several immunotherapy strategies have been tested in colorectal cancer. This review provides an understanding of the mechanisms involved and identifies innovating therapeutic strategies.