Review
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World J Gastroenterol. Apr 14, 2014; 20(14): 3976-3985
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3976
Post-infectious irritable bowel syndrome: Mechanistic insights into chronic disturbances following enteric infection
Jennifer K Beatty, Amol Bhargava, Andre G Buret
Jennifer K Beatty, Amol Bhargava, Andre G Buret, Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Author contributions: Beatty JK, Bhargava A and Buret AG wrote this paper.
Supported by Natural Sciences and Engineering Research Council of Canada (individual operating and CREATE)
Correspondence to: Andre G Buret, PhD, Professor, Department of Biological Sciences, University of Calgary, 2500 University Drive, NW, Calgary, AB T2N 1N4, Canada. aburet@ucalgary.ca
Telephone: +1-403-2202817  Fax: +1-403-2899311
Received: November 21, 2013
Revised: January 9, 2014
Accepted: February 17, 2014
Published online: April 14, 2014
Core Tip

Core tip: This review discusses the long-term consequences of acute enteric infections that may serve to trigger post-infectious irritable bowel syndrome, a routinely diagnosed disorder. This unique discussion elucidates novel initiation mechanisms, underlying pathophysiological features of post-infectious irritable bowel syndrome, employed by commonly encountered enteric pathogens.