Wang YF, Feng FL, Zhao XH, Ye ZX, Zeng HP, Li Z, Jiang XQ, Peng ZH. Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer. World J Gastroenterol 2014; 20(14): 4085-4092 [PMID: 24744600 DOI: 10.3748/wjg.v20.i14.4085]
Corresponding Author of This Article
Yun-Feng Wang, PhD, Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, No. 450, Teng Yue Road, Shanghai 200090, China. wangyunfeng197911@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 6 Evaluation of diagnostic value of a single tumor marker in 78 gallbladder cancer cases
Diagnostic value
n
Sensitivity
Specificity
Positive likelihood ratio
Negative likelihood ratio
CEA
9
11.5%
97.4%
4.42
0.91
CA199
56
71.7%
96.1%
18.4
0.29
CA242
50
64.1%
98.7%
49.5
0.36
CA125
35
44.8%
96.2%
11.79
0.57
Table 7 Analyses of different combinations of markers in gallbladder cancer diagnosis
Group
n
1 item (+)
2 item (+)
3 item (+)
4 item (+)
Normal
78
4 (5.1)
3 (3.8)
0 (0)
0 (0)
Gallbladder cancer (GBC)
78
71 (91.0)
67 (85.9)
54 (69.2)
7 (8.9)
Positive likelihood rate
17.8%
22.6%
100%
100%
Table 8 Correlations between carcinoembryonic antigen, cancer antigen 125, cancer antigen 242, and cancer antigen 199 expression and lymph node metastasis
Table 10 Results of Cox proportional hazards model for multivariate regression analysis
Prognostic factor
Parameter estimate
Waldχ2
P value
HR
95%CI
CEA
-0.043
0.498
0.48
0.957
0.849-1.080
CA199
0.005
12.076
0.001
1.005
1.002-1.009
CA242
-0.007
0.386
0.535
0.993
0.972-1.015
CA125
0.003
0.714
0.398
1.003
0.996-1.009
Surgical modality
0.569
2.450
0.118
1.766
0.866-3.599
LN metastasis
1.191
3.276
0.07
3.291
0.906-11.957
Position (neck)
-1.578
6.358
0.012
0.206
0.061-0.704
Age
-0.010
0.073
0.787
0.990
0.922-1.063
Sex
0.796
2.508
0.113
2.216
0.828-5.932
Citation: Wang YF, Feng FL, Zhao XH, Ye ZX, Zeng HP, Li Z, Jiang XQ, Peng ZH. Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer. World J Gastroenterol 2014; 20(14): 4085-4092