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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Inflammatory diseases modelling in zebrafish  
Camila Idelí Morales Fénero, Alicia Angelina Colombo Flores, Niels Olsen Saraiva Câmara 
World J Exp Med 6(1):9-20. Published online Feb 20, 2016. doi: 10.5493/wjem.v6.i1.9
2
Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review  
Miguel Angel Chiurillo 
World J Exp Med 5(2):84-102. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.84
3
Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?  
Dubravka Kojic, Benedikt H Siegler, Florian Uhle, Christoph Lichtenstern, Peter P Nawroth, Markus A Weigand, Stefan Hofer, Thorsten Brenner 
World J Exp Med 5(2):50-63. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.50
4
Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment  
Mohamed Hassan, Denis Selimovic, Matthias Hannig, Youssef Haikel, Robert T Brodell, Mossaad Megahed 
World J Exp Med 5(4):206-217. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.206
5
Does physical therapy and rehabilitation improve outcomes for diabetic foot ulcers?  
Yasemin Turan, Bulent M Ertugrul, Benjamin A Lipsky, Kevser Bayraktar 
World J Exp Med 5(2):130-139. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.130
6
Spotlights on immunological effects of reactive nitrogen species: When inflammation says nitric oxide  
Andrea Predonzani, Bianca Calì, Andrielly HR Agnellini, Barbara Molon 
World J Exp Med 5(2):64-76. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.64
7
8
Internal ribosome entry site-based vectors for combined gene therapy  
Edith Renaud-Gabardos, Fransky Hantelys, Florent Morfoisse, Xavier Chaufour, Barbara Garmy-Susini, Anne-Catherine Prats 
World J Exp Med 5(1):11-20. Published online Feb 20, 2015. doi: 10.5493/wjem.v5.i1.11
9
10
Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages  
Remo George, Renata Cavalcante, Celso Carvalho Jr, Elyana Marques, Jonathan B Waugh, M Tino Unlap 
World J Exp Med 5(3):164-181. Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.164
11
Effect of aging on stem cells  
Abu Shufian Ishtiaq Ahmed, Matilda HC Sheng, Samiksha Wasnik, David J Baylink, Kin-Hing William Lau 
World J Exp Med 7(1):1-10. Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.1
12
Consolidated and emerging inflammatory markers in coronary artery disease  
Valter Lubrano, Silvana Balzan 
World J Exp Med 5(1):21-32. Published online Feb 20, 2015. doi: 10.5493/wjem.v5.i1.21
13
Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity  
Alexander Dontsov, Anna Koromyslova, Mikhail Ostrovsky, Natalia Sakina 
World J Exp Med 6(4):63-71. Published online Nov 20, 2016. doi: 10.5493/wjem.v6.i4.63
14
High-level disinfection of gastrointestinal endoscope reprocessing  
King-Wah Chiu, Lung-Sheng Lu, Shue-Shian Chiou 
World J Exp Med 5(1):33-39. Published online Feb 20, 2015. doi: 10.5493/wjem.v5.i1.33
15
Aging: A mitochondrial DNA perspective, critical analysis and an update  
Inna N Shokolenko, Glenn L Wilson, Mikhail F Alexeyev 
World J Exp Med 4(4):46-57. Published online Nov 20, 2014. doi: 10.5493/wjem.v4.i4.46
16
Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis  
Afsie Sabokbar, Sara Afrough, David J Mahoney, Yoshinobu Uchihara, Catherine Swales, Nicholas A Athanasou 
World J Exp Med 7(2):49-57. Published online May 20, 2017. doi: 10.5493/wjem.v7.i2.49
17
Eurytrematosis: An emerging and neglected disease in South Brazil  
Claiton Ismael Schwertz, Neuber Jose Lucca, Aleksandro Schafer da Silva, Piotr Baska, Gustavo Bonetto, Mateus Eloir Gabriel, Fábio Centofanti, Ricardo Evandro Mendes 
World J Exp Med 5(3):160-163. Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.160
18
Selected suitable seed cell, scaffold and growth factor could maximize the repair effect using tissue engineering method in spinal cord injury  
Wen-Chen Ji, Xiao-Wei Zhang, Yu-Sheng Qiu 
World J Exp Med 6(3):58-62. Published online Aug 20, 2016. doi: 10.5493/wjem.v6.i3.58
19
Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice  
Yang Liu, Nicole L Jennings, Anthony M Dart, Xiao-Jun Du 
World J Exp Med 2(2):30-36. Published online Apr 20, 2012. doi: 10.5493/wjem.v2.i2.30
20
21
Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients  
Ekaterina Krasimirova, Tsvetelina Velikova, Ekaterina Ivanova-Todorova, Kalina Tumangelova-Yuzeir, Desislava Kalinova, Vladimira Boyadzhieva, Nikolay Stoilov, Tsvetelina Yoneva, Rasho Rashkov, Dobroslav Kyurkchiev 
World J Exp Med 7(3):84-96. Published online Aug 20, 2017. doi: 10.5493/wjem.v7.i3.84
22
Interferon-γ: Promising therapeutic target in atherosclerosis  
Joe WE Moss, Dipak P Ramji 
World J Exp Med 5(3):154-159. Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.154
23
Computed tomography-based finite element analysis to assess fracture risk and osteoporosis treatment  
Kazuhiro Imai 
World J Exp Med 5(3):182-187. Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.182
24
Recent clinical trials of cancer immunogene therapy in companion animals  
Liliana M E Finocchiaro, Gerardo C Glikin 
World J Exp Med 7(2):42-48. Published online May 20, 2017. doi: 10.5493/wjem.v7.i2.42
25
Polycystins and mechanotransduction: From physiology to disease  
Christina Piperi, Efthimia K Basdra 
World J Exp Med 5(4):200-205. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.200
26
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies  
Mohamed Hassan, Denis Selimovic, Abdelouahid El-Khattouti, Hanan Ghozlan, Youssef Haikel, Ola Abdelkader 
World J Exp Med 2(2):7-25. Published online Apr 20, 2012. doi: 10.5493/wjem.v2.i2.7
27
Combinations of vascular endothelial growth factor pathway inhibitors with metronomic chemotherapy: Rational and current status  
Antonia Digklia, Ioannis A Voutsadakis 
World J Exp Med 4(4):58-67. Published online Nov 20, 2014. doi: 10.5493/wjem.v4.i4.58
28
Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration  
Anabel S de la Garza-Rodea, Hester Boersma, Cheryl Dambrot, Antoine AF de Vries, Dirk W van Bekkum, Shoshan Knaän-Shanzer 
World J Exp Med 5(2):140-153. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.140
29
Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis  
Pedro Xavier-Elsas, Daniela Masid-de-Brito, Bruno Marques Vieira, Maria Ignez C Gaspar-Elsas 
World J Exp Med 7(1):11-24. Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.11
30
Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis  
Shizuyo Tsujimura, Yoshiya Tanaka 
World J Exp Med 5(4):225-231. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.225
31
Endothelium-derived essential signals involved in pancreas organogenesis  
Dodanim Talavera-Adame, Donald C Dafoe 
World J Exp Med 5(2):40-49. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.40
32
Discernment scheme for paraquat poisoning: A five-year experience in Shiraz, Iran  
Saeed Kavousi-Gharbi, Reza Jalli, Akbar Rasekhi-Kazerouni, Zahra Habibagahi, Sayed Mahdi Marashi 
World J Exp Med 7(1):31-39. Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.31
33
Comments on human eurytremiasis in Brazil  
Hudson Alves Pinto, Alan Lane de Melo 
World J Exp Med 6(2):55-57. Published online May 20, 2016. doi: 10.5493/wjem.v6.i2.55
34
Anti-cancer potential of litchi seed extract  
Chih-Cheng Lin, Yuan-Chiang Chung, Chih-Ping Hsu 
World J Exp Med 3(4):56-61. Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.56
35
Enzymatic antioxidant system in vascular inflammation and coronary artery disease  
Valter Lubrano, Silvana Balzan 
World J Exp Med 5(4):218-224. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.218
36
Multifunctional biomimetic spinal cord: New approach to repair spinal cord injuries  
Yang Liu, Qian Li, Bin Zhang, De-Xiang Ban, Shi-Qing Feng 
World J Exp Med 7(3):78-83. Published online Aug 20, 2017. doi: 10.5493/wjem.v7.i3.78
37
Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options  
Cecilia Söderberg-Nauclér, John Inge Johnsen 
World J Exp Med 5(1):1-10. Published online Feb 20, 2015. doi: 10.5493/wjem.v5.i1.1
38
Mechanotransduction in bone: Intervening in health and disease  
Anastasia Spyropoulou, Efthimia K Basdra 
World J Exp Med 3(4):74-86. Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.74
39
Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy  
Pedro Xavier-Elsas, Renato Nunes Ferreira, Maria Ignez C Gaspar-Elsas 
World J Exp Med 7(3):58-77. Published online Aug 20, 2017. doi: 10.5493/wjem.v7.i3.58
40
Statin escape phenomenon: Fact or fiction?  
Fotios Barkas, Moses Elisaf, Eleftherios Klouras, Theodora Dimitriou, Nikolaos Tentolouris, Evangelos Liberopoulos 
World J Exp Med 7(1):25-30. Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.25
41
Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis  
Jean Huang, Rudruidee Karnchanasorn, Horng-Yih Ou, Wei Feng, Lee-Ming Chuang, Ken C Chiu, Raynald Samoa 
World J Exp Med 5(4):232-243. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.232
42
Epigallocatechin-3-gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor  
Masaki Tabuchi, Sumio Hayakawa, Eiko Honda, Kana Ooshima, Tatsuki Itoh, Koji Yoshida, Ah-Mee Park, Hideaki Higashino, Mamoru Isemura, Hiroshi Munakata 
World J Exp Med 3(4):100-107. Published online Nov 20, 2013. doi: 10.5493/wjem.v3.i4.100
43
Natural compounds as anticancer agents: Experimental evidence  
Jiao Wang, Yang-Fu Jiang 
World J Exp Med 2(3):45-57. Published online Jun 20, 2012. doi: 10.5493/wjem.v2.i3.45
44
Impact and risk factors of post-stroke bone fracture  
Kang Huo, Syed I Hashim, Kimberley L Y Yong, Hua Su, Qiu-Min Qu 
World J Exp Med 6(1):1-8. Published online Feb 20, 2016. doi: 10.5493/wjem.v6.i1.1
45
How reliable is online diffusion of medical information targeting patients and families?  
Pedro Xavier-Elsas, Sandra Epifânio Bastos, Maria Ignez C Gaspar-Elsas 
World J Exp Med 5(4):244-250. Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.244
46
Oxidative stress and labile plasmatic iron in anemic patients following blood therapy  
Marília Sabo Fernandes, Tatiana Tamborena Rissi, Luisa Zuravski, Juliana Mezzomo, Carmen Regla Vargas, Vanderlei Folmer, Félix Alexandre Antunes Soares, Vanusa Manfredini, Mushtaq Ahmed, Robson Luiz Puntel 
World J Exp Med 4(3):38-45. Published online Aug 20, 2014. doi: 10.5493/wjem.v4.i3.38
47
Genetic test in multiple endocrine neoplasia type 1 syndrome: An evolving story  
Francesca Marini, Francesca Giusti, Maria Luisa Brandi 
World J Exp Med 5(2):124-129. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.124
48
Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein  
Izolde Bouloukaki, Charalampos Mermigkis, Eleftherios M Kallergis, Violeta Moniaki, Eleni Mauroudi, Sophia E Schiza 
World J Exp Med 5(2):77-83. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.77
49
Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus  
Hiroyuki Konya, Masayuki Miuchi, Kahori Satani, Satoshi Matsutani, Yuzo Yano, Taku Tsunoda, Takashi Ikawa, Toshihiro Matsuo, Fumihiro Ochi, Yoshiki Kusunoki, Masaru Tokuda, Tomoyuki Katsuno, Tomoya Hamaguchi, Jun-ichiro Miyagawa, Mitsuyoshi Namba 
World J Exp Med 5(2):110-119. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.110
50
Mood disorders: A potential link between ghrelin and leptin on human body?  
Stalo Zarouna, Greta Wozniak, Anastasia Ioannis Papachristou 
World J Exp Med 5(2):103-109. Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.103