Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. May 20, 2015; 5(2): 40-49
Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.40
Endothelium-derived essential signals involved in pancreas organogenesis
Dodanim Talavera-Adame, Donald C Dafoe
Dodanim Talavera-Adame, Donald C Dafoe, Comprehensive Transplant Center, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Dodanim Talavera-Adame, Donald C Dafoe, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Author contributions: Talavera-Adame D and Dafoe DC contributed equally to this work; Talavera-Adame D and Dafoe DC design the research, contributed new reagents/analytic tools, analyzed the data, and wrote the paper; Talavera-Adame D performed the research.
Supported by Eris M. Field Endowment for Diabetes Research assigned to Donald C Dafoe.
Conflict-of-interest: The authors have nothing to declare regarding any conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Donald C Dafoe, MD, Professor of Surgery, Clinical Professor of Surgery, UCLA, Eris M. Field Chair in Diabetes Research, Vice-Chair of Education, Director, Comprehensive Transplant Center, Department of Surgery, Cedars-Sinai Medical Center, 8635 W. Third Street, Suite 590W, Los Angeles, CA 90048, United States.
Telephone: +1-310-4237899 Fax: +1-310-4233864
Received: December 6, 2014
Peer-review started: December 6, 2014
First decision: January 20, 2015
Revised: March 18, 2015
Accepted: April 10, 2015
Article in press: April 12, 2015
Published online: May 20, 2015
Core Tip

Core tip: Many studies have demonstrated that endothelial cells (ECs) have an important role in organogenesis. For instance, during embryogenesis, aortic ECs provide specific factors that maintain the expression of key genes for pancreas development. Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells. In addition, by the end of the gestation and close to birth, pancreatic islets contain immature beta cells with the capacity to express factors that recruit ECs from the surrounding microenvironment and form a functional unit that will lasts for the whole life of the individual. In the present review, we will analyze the current endothelial-derived factors called angiocrine factors that are essential in organogenesis and we will focus the role of these factors in pancreas development and pancreatic beta cells.