Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.50
Peer-review started: November 27, 2014
First decision: December 26, 2014
Revised: January 9, 2015
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: May 20, 2015
Core tip: Sepsis is a complex continuum of disturbed systems. Despite the presence of clinical consensus criteria, the early diagnosis especially in the perioperative setting is challenging. A magnitude of potential new biomarkers is tested for this purpose, but evidence is mounting that due to the complex nature of the syndrome, biomarkers are rather complementary tools for clinical decision making than “magic bullets”. Moreover, biomarkers are also evaluated for therapy guidance, linking diagnostic results to an individual therapeutic regime. This review summarizes the developments in the biomarker field, aiming to provide an overview about current targets and their limitations.