Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.154
Peer-review started: March 18, 2015
First decision: April 10, 2015
Revised: April 21, 2015
Accepted: May 7, 2015
Article in press: May 8, 2015
Published online: August 20, 2015
Core tip: Atherosclerosis is an inflammatory disorder of the vasculature and studies in mouse model systems have highlighted the beneficial effects of counteracting inflammation in limiting the progression of this disease. Due to its key role in inflammation and atherosclerosis development, interferon-γ (IFN-γ) is seen as a promising therapeutic target. In this editorial we discuss the role of IFN-γ in atherosclerosis together with potential therapeutic approaches against this cytokine and its key downstream targets.