Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Feb 20, 2015; 5(1): 1-10
Published online Feb 20, 2015. doi: 10.5493/wjem.v5.i1.1
Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options
Cecilia Söderberg-Nauclér, John Inge Johnsen
Cecilia Söderberg-Nauclér, Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
John Inge Johnsen, Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, S-171 76 Stockholm, Sweden
Author contributions: Söderberg-Nauclér C and Johnsen JI solely contributed to this paper.
Supported by Grants from Ragnar Söderbergs Foundation; The Swedish Children’s Cancer Foundation; BILTEMA Foundation; Family Ehring Perssons Foundation; Sten A Olssons Foundation; Stichting af Jochnicks Foundation; The Swedish Cancer Society, The Swedish Research Council, the Märta and Gunnar V Philipson Foundation; The Hans and Märit Rausing Charitable Fund; The Dämman Foundation; Swedish Society for Medical Research (SLS), Goljes Memory Foundation; Magnus Bergvalls Foundation; Swedish Society for Medical Research (SSMF) and Tore Nilsons Foundation.
Conflict-of-interest: The authors have no conflicting financial interests (although CS-N earlier held an independent grant from Roche supporting the clinical trial evaluating the efficacy and safety of valganciclovir treatment in glioblastoma patients).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Cecilia Söderberg-Nauclér, MD, PhD, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:03, 171 76 Stockholm, Sweden.
Telephone: +46-8-51779896 Fax: +46-8-313147
Received: October 1, 2014
Peer-review started: October 5, 2014
First decision: October 28, 2014
Revised: November 13, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: February 20, 2015
Core Tip

Core tip: Cytomegalovirus (CMV) has recently been detected in several human cancers. These findings have raised several concerns whether this virus is the cause or a passenger during oncogenesis. Here we discuss the pathogenesis behind CMV infection, its potential as an onco- or oncomodulatory-virus and possible modes of medical interventions.