Published online Aug 20, 2017. doi: 10.5493/wjem.v7.i3.78
Peer-review started: March 29, 2017
First decision: April 17, 2017
Revised: May 26, 2017
Accepted: June 12, 2017
Article in press: June 13, 2017
Published online: August 20, 2017
Core tip: Traumatic spinal cord injury often leads to serious consequences and also adds great burden to families and society. Usually people believe that the regeneration of lost tissue is limited after central nervous system injury. Due to these reasons, we would like to provide a new bionic spinal cord to reduce the negative effect of glial scar on nerve regeneration. We design biomimetic spinal cord by the combination of basic fibroblast growth factor modified thermosensitive hydrogel and acellular spinal cord scaffold, which is conducive to the designation of a three-dimensional composite scaffold more suitable for cell growth, and corresponding mechanical properties and biodegradability more close to the structure of normal spinal cord.