Published online Nov 20, 2014. doi: 10.5493/wjem.v4.i4.58
Revised: July 16, 2014
Accepted: September 6, 2014
Published online: November 20, 2014
Core tip: Metronomic chemotherapy has the potential to reduce the toxicity of chemotherapy administered with conventional schedules. In addition, understanding of the importance of angiogenesis in the mechanism of action of metronomic schedules provides a rational to combine this type of administration with targeted agents against the vascular endothelial growth factor signaling pathway.