Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.182
Peer-review started: September 28, 2014
First decision: November 14, 2014
Revised: April 23, 2015
Accepted: May 7, 2015
Article in press: May 8, 2015
Published online: August 20, 2015
Core tip: Finite element analysis (FEA) is a computer technique of structural stress analysis developed in engineering mechanics. With the faster computers, better FEA, using computed tomography (CT) has been developed. This CT-based finite element analysis (CT/FEA) has provided clinicians with useful data. In this review, the mechanism of CT/FEA, validation studies of CT/FEA to evaluate accuracy and reliability in human bones, and clinical application studies to assess fracture risk and osteoporosis treatment are overviewed.