Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.11
Peer-review started: September 14, 2016
First decision: October 21, 2016
Revised: November 1, 2016
Accepted: November 27, 2016
Article in press: November 29, 2016
Published online: February 20, 2017
Core tip: The bone-marrow is exquisitely sensitive to regulation by systemic events, which selectively increase production of different blood cell types to meet transient increases in demand following injury. An association between stress and allergy has long been known, but its mechanisms remain incompletely understood. The exploration of underlying mechanisms in a variety of murine models yielded evidence of separate but interrelated roles for adrenal glucocorticoid hormones and cysteinyl-leukotrienes in coupling systemic events to bone-marrow responses in vivo. We here discuss how these unlikely partners work together to promote eosinophilia but through subtle mechanisms also limit its magnitude.