Roberto Mazzanti, Umberto Arena, Renato Tassi, Department of Experimental and Clinical Medicine, School of Sciences of Human Health, University of Florence, 50134 Firenze, Italy
Author contributions: Mazzanti R wrote the general part of the article, epidemiology, treatment and a general review of the subject; Tassi R wrote most of the biology of HCC, while Arena U wrote the diagnostic aspects.
Supported by Fondazione Italiana per lo Studio del Fegato - Italian Liver Foundation, Firenze, via Banchi 6, 50123, Italy.
Conflict-of-interest statement: The authors declare no any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Roberto Mazzanti, MD, Professor, Department of Experimental and Clinical Medicine, School of Sciences of Human Health, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy. firstname.lastname@example.org
Telephone: +39-055-416635 Fax: +39-055-417123
Received: July 30, 2015
Peer-review started: July 31, 2015
First decision: September 16, 2015
Revised: December 14, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: February 20, 2016