Published online Feb 20, 2017. doi: 10.5493/wjem.v7.i1.1
Peer-review started: August 29, 2016
First decision: November 14, 2016
Revised: November 19, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 20, 2017
Core tip: Stem cells have the remarkable self-renewal capability and the amazing ability to differentiate into all cell types. It is generally believe that stem cells are the main source that provides cells to repair and regenerate damaged tissues and organs. However, there is now compelling evidence that the aging process has a deleterious effect on stem cells, and that the aging effects on stem cells may have play essential roles in the pathophysiology of the various aging-associated diseases. This review discusses briefly the relationship of aging-associated stem cell dysfunction and the various aging-associated ailments, and several proposed concepts on the molecular mechanism of aging-related stem cell dysfunction.