Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Nov 20, 2015; 5(4): 218-224
Published online Nov 20, 2015. doi: 10.5493/wjem.v5.i4.218
Enzymatic antioxidant system in vascular inflammation and coronary artery disease
Valter Lubrano, Silvana Balzan
Valter Lubrano, Department of Laboratory Medicine, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy
Silvana Balzan, Institute of Clinical Phisiology, CNR, 56124 Pisa, Italy
Author contributions: Lubrano V drafted of the text; Balzan S contributed to review and literature search.
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors that contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Valter Lubrano, PhD, Department of Laboratory Medicine, Fondazione G. Monasterio CNR-Regione Toscana, Via Moruzzi n° 1, 56124 Pisa, Italy.
Telephone: +39-50-3152199 Fax: +39-50-3153454
Received: June 16, 2015
Peer-review started: June 20, 2015
First decision: July 27, 2015
Revised: October 12, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: November 20, 2015
Core Tip

Core tip: This review shows that antioxidant enzymes are very important factors for the prevention and treatment of atherosclerotic disease, but more studies are required to understand whether they can be used as markers for diagnosis of coronary artery disease. The presence of polymorphic genes that increases the activity and expression of these enzymes can be considered important for the development of new therapeutic strategies. In our opinion further efforts should be directed especially on this last point, in order to find new therapies to increase the function of antioxidant enzymes in metabolic disease or other risk factors.