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Editorial
Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers 
Yi-Fang Han, Guang-Wen Cao 
World J Gastroenterol 18(47):6865-6873. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6865
Regenerative medicine technology applied to gastroenterology: Current status and future perspectives 
Giuseppe Orlando 
World J Gastroenterol 18(47):6874-6875. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6874
Topic Highlight
Present and future cell therapies for pancreatic beta cell replenishment 
Juan Domínguez-Bendala, Camillo Ricordi 
World J Gastroenterol 18(47):6876-6884. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6876
Macro- or microencapsulation of pig islets to cure type 1 diabetes 
Denis Dufrane, Pierre Gianello 
World J Gastroenterol 18(47):6885-6893. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6885
Esophagus and regenerative medicine 
Ricardo Londono, Blair A Jobe, Toshitaka Hoppo, Stephen F Badylak 
World J Gastroenterol 18(47):6894-6899. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6894
Esophageal tissue engineering: A new approach for esophageal replacement 
Giorgia Totonelli, Panagiotis Maghsoudlou, Jonathan M Fishman, Giuseppe Orlando, Tahera Ansari, Paul Sibbons, Martin A Birchall, Agostino Pierro, Simon Eaton, Paolo De Coppi 
World J Gastroenterol 18(47):6900-6907. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6900
How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology? 
Marco Carbone, Jan Lerut, James Neuberger 
World J Gastroenterol 18(47):6908-6917. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6908
Tissue engineering for neuromuscular disorders of the gastrointestinal tract 
Kenneth L Koch, Khalil N Bitar, John E Fortunato 
World J Gastroenterol 18(47):6918-6925. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6918
Liver bioengineering: Current status and future perspectives 
Christopher Booth, Tom Soker, Pedro Baptista, Christina L Ross, Shay Soker, Umar Farooq, Robert J Stratta, Giuseppe Orlando 
World J Gastroenterol 18(47):6926-6934. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6926
Original Article
Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis 
Kazuya Shinmura, Masanori Goto, Hong Tao, Shun Matsuura, Tomonari Matsuda, Haruhiko Sugimura 
World J Gastroenterol 18(47):6935-6942. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6935
Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B 
Suk Bae Kim, Il Han Song, Young Min Kim, Ran Noh, Ha Yan Kang, Hyang Ie Lee, Hyeon Yoong Yang, An Na Kim, Hee Bok Chae, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee, Heon Young Lee 
World J Gastroenterol 18(47):6943-6950. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6943
Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats 
Khanitta Srimuangwong, Chainarong Tocharus, Jiraporn Tocharus, Apichart Suksamrarn, Pornphorm Yoysungnoen Chintana 
World J Gastroenterol 18(47):6951-6959. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6951
Brief Article
Endoscopic findings in patients with Schatzki rings: Evidence for an association with eosinophilic esophagitis 
Michaela Müller, Alexander J Eckardt, Annette Fisseler-Eckhoff, Susanne Haas, Ines Gockel, Till Wehrmann 
World J Gastroenterol 18(47):6960-6966. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6960
Sex-dimorphic adverse drug reactions to immune suppressive agents in inflammatory bowel disease 
Zuzana Zelinkova, Evelien Bultman, Lauran Vogelaar, Cheima Bouziane, Ernst J Kuipers, C Janneke van der Woude 
World J Gastroenterol 18(47):6967-6973. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6967
Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis 
Yasushi Ihama, Akira Hokama, Kenji Hibiya, Kazuto Kishimoto, Manabu Nakamoto, Tetsuo Hirata, Nagisa Kinjo, Haley L Cash, Futoshi Higa, Masao Tateyama, Fukunori Kinjo, Jiro Fujita 
World J Gastroenterol 18(47):6974-6980. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6974
-449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis 
Ranji Hayashi, Tomomitsu Tahara, Tsukasa Yamaaki, Takashi Saito, Kazuhiro Matsunaga, Nobuhiko Hayashi, Atsushi Fukumura, Kazuaki Ozaki, Masakatsu Nakamura, Hisakazu Shiroeda, Mikihiro Tsutsumi, Tomoyuki Shibata, Tomiyasu Arisawa 
World J Gastroenterol 18(47):6981-6986. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6981
Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B 
Tae Jung Yun, Jin Yong Jung, Chang Ha Kim, Soon Ho Um, Hyonggin An, Yeon Seok Seo, Jin Dong Kim, Hyung Joon Yim, Bora Keum, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu 
World J Gastroenterol 18(47):6987-6995. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6987
Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures 
Yu Jin Kim, Dong Hyun Sinn, Geum-Youn Gwak, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee 
World J Gastroenterol 18(47):6996-7002. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6996
Interleukin-28 and hepatitis C virus genotype-4: Treatment-induced clearance and liver fibrosis 
Moutaz Derbala, Nasser Rizk, Fatima Shebl, Saad Alkaabi, Nazeeh Eldweik, Anil John, Manik Sharma, Rafie Yaqoob, Muneera Almohanadi, Mohammed Butt, Khaled Alejji 
World J Gastroenterol 18(47):7003-7008. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7003
Predictive factors of endoscopic submucosal dissection procedure time for gastric superficial neoplasia 
Zhong-Sheng Lu, Yun-Sheng Yang, Dan Feng, Shu-Fang Wang, Jing Yuan, Jin Huang, Xiang-Dong Wang, Jiang-Yun Meng, Hong Du, Hong-Bin Wang 
World J Gastroenterol 18(47):7009-7014. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7009
Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment 
Jun Zhao, Chang-Zheng Du, Ying-Shi Sun, Jin Gu 
World J Gastroenterol 18(47):7015-7020. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7015
Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection 
Liang Huang, Jing Li, Jian-Jun Yan, Cai-Feng Liu, Meng-Chao Wu, Yi-Qun Yan 
World J Gastroenterol 18(47):7021-7025. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7021
Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy 
Jian Ang, Liang Hu, Pin-Tong Huang, Jin-Xiu Wu, Ling-Na Huang, Chun-Hui Cao, Yi-Xiong Zheng, Li Chen 
World J Gastroenterol 18(47):7026-7032. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7026
Major influence of renal function on hyperlipidemia after living donor liver transplantation 
Qi Ling, Kai Wang, Di Lu, Hai-Jun Guo, Wen-Shi Jiang, Xiang-Xiang He, Xiao Xu, Shu-Sen Zheng 
World J Gastroenterol 18(47):7033-7039. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7033
Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats 
Dan-Hong Yang, Zai-Yuan Ye, Yuan-Jun Xie, Xu-Jun He, Wen-Juan Xu, Wei-Ming Zhou 
World J Gastroenterol 18(47):7040-7047. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7040
Hepatic focal nodular hyperplasia in children: Imaging features on multi-slice computed tomography 
Qing-Yu Liu, Wei-Dong Zhang, Dong-Ming Lai, Ying Ou-yang, Ming Gao, Xiao-Feng Lin 
World J Gastroenterol 18(47):7048-7055. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7048
Radical treatment of stage IV pancreatic cancer by the combination of cryosurgery and iodine-125 seed implantation 
Ji-Bing Chen, Jia-Liang Li, Li-Hua He, Wei-Qun Liu, Fei Yao, Jian-Ying Zeng, Yi Zhang, Ke-Qiang Xu, Li-Zhi Niu, Jian-Sheng Zuo, Ke-Cheng Xu 
World J Gastroenterol 18(47):7056-7062. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7056
Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats 
Jing-Wei Mao, Xiao-Mei He, Hai-Ying Tang, Ying-De Wang 
World J Gastroenterol 18(47):7063-7069. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7063
Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth 
Ming Xiu, Ya-Hui Liu, David R Brigstock, Fang-Hui He, Rui-Juan Zhang, Run-Ping Gao 
World J Gastroenterol 18(47):7070-7078. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7070
Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice 
Qing-E Tian, Huan-De Li, Miao Yan, Hua-Lin Cai, Qin-You Tan, Wen-Yuan Zhang 
World J Gastroenterol 18(47):7079-7086. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7079
Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice 
Gui-Jun Zhao, Li-Xia Xu, Eagle SH Chu, Ning Zhang, Jia-Yun Shen, Alatangaole Damirin, Xiao-Xing Li 
World J Gastroenterol 18(47):7087-7092. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7087
Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities 
Jiu-Da Zhao, Pai-Li Geng, Zhan-Quan Li, Sen Cui, Jun-Hui Zhao, Li-Juan Wang, Jin-Zhang Li, Fa-Xiang Ji, Guo-Yuan Li, Guo-Shuang Shen, Ming-Zhe Lin, Cun-Fang Shen, Cheng-Zhu Cao 
World J Gastroenterol 18(47):7093-7099. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7093
Case Report
Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: A case report 
Yun-Lu Tao, Zhen-Jun Wang, Jia-Gang Han, Ping Wei 
World J Gastroenterol 18(47):7100-7103. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7100
Management of surgical splenorenal shunt-related hepatic myelopathy with endovascular interventional techniques 
Mao-Qiang Wang, Feng-Yong Liu, Feng Duan 
World J Gastroenterol 18(47):7104-7108. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7104
Retrieval-balloon-assisted enterography in post-pancreaticoduodenectomy endoscopic retrograde cholangiopancreatography 
Ming Zhuang, Wen-Jie Zhang, Jun Gu, Ying-Bin Liu, Xue-Feng Wang 
World J Gastroenterol 18(47):7109-7112. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7109
Primary ∆4-3-oxosteroid 5β-reductase deficiency: Two cases in China 
Jing Zhao, Ling-Juan Fang, Kenneth DR Setchell, Rui Chen, Li-Ting Li, Jian-She Wang 
World J Gastroenterol 18(47):7113-7117. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7113
Esophageal granular cell tumors: Report of 9 cases and a literature review 
Guo-Qiang Xu, Hong-Tan Chen, Cheng-Fu Xu, Xiao-Dong Teng 
World J Gastroenterol 18(47):7118-7121. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7118
Successful disintegration, dissolution and drainage of intracholedochal hematoma by percutaneous transhepatic intervention 
Jian-Jie Qin, Yong-Xiang Xia, Ling Lv, Zhao-Jing Wang, Feng Zhang, Xue-Hao Wang, Bei-Cheng Sun 
World J Gastroenterol 18(47):7122-7126. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7122
Gastric intramural hematoma accompanied by severe epigastric pain and hematemesis after endoscopic mucosal resection 
Peng Sun, Shi-Yun Tan, Guo-Hai Liao 
World J Gastroenterol 18(47):7127-7130. Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7127