Brief Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 21, 2012; 18(47): 7079-7086
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7079
Table 1 Tumor inhibition rate and immune organ index (n = 10)
GroupTumor weight (g)Inhibition rate (%)Spleen indexThymus index
ADM + RFP5.37 ± 1.31a60.000.51 ± 0.28a0.15 ± 0.04
ADM5.32 ± 2.03a60.360.39 ± 0.17a0.13 ± 0.04
NS13.42 ± 1.03-0.74 ± 0.210.15 ± 0.09
ADM + APS (50 mg/kg)3.64 ± 1.54ac72.88c0.65 ± 0.22c0.15 ± 0.05
ADM + APS (100 mg/kg)3.57 ± 1.66ac73.40c0.62 ± 0.34c0.20 ± 0.06c
ADM + APS (200 mg/kg)3.01 ± 1.95ac77.57c0.67 ± 0.20c0.47 ± 0.12ac
ADM + VER4.75 ± 1.86a69.450.50 ± 0.17a0.13 ± 0.03
Table 2 Expression of interleukin-1α, interleukin-2, interleukin-6, tumor necrosis factor-α, and interleukin-10 (n = 10)
Groupmean ± SD (pg/mL)
IL-1αIL-2IL-6TNF-αIL-10
ADM + RFP5.89 ± 2.126.11 ± 2.9a10.99 ± 2.09a9.00 ± 1.2155.98 ± 2.43
ADM4.63 ± 3.25.23 ± 2.12a10.78 ± 3.13a8.01 ± 1.2254.01 ± 2.33
NS13.21 ± 2.01c11.35 ± 2.09c29.55 ± 8.97c23.1 ± 1.83c56.67 ± 4.32
ADM + APS (50 mg/kg)14.34 ± 1.78c12.11 ± 3.08c41.57 ± 6.42ac29.97 ± 4.09c41.23 ± 3.12ac
ADM + APS (100 mg/kg)25.31 ± 2.98ac19.98 ± 3.21ac38.82 ± 5.88ac33.23 ± 3.99ac27.23 ± 7.68ac
ADM + APS (200 mg/kg)22.45 ± 4.01ac26.67 ± 7.21ac40.99 ± 5.54ac44.78 ± 3.98ac24.87 ± 5.78ac
ADM + VER7.34 ± 2.115.77 ± 2.119.34 ± 1.75a9.11 ± 2.0150.66 ± 1.12
Table 3 Multidrug resistance 1 mRNA expression in tumor tissue (2-∆∆Ct) (n = 10)
Group2-∆∆Ct ( mean ± SD )
ADM + RFP5.02 ± 1.82
ADM4.26 ± 1.51
NS1.02 ± 0.05ac
ADM + APS (50 mg/kg)0.48 ± 0.13ac
ADM + APS (100 mg/kg)0.36 ± 0.03ac
ADM + APS (200 mg/kg)0.21 ± 0.04ac
ADM + VER0.28 ± 0.09ac