Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures

Figure 1 Probability of complete virologic response during the treatment period.

Figure 2 Detailed clinical course of a patient who did not achieve complete virologic response. The patient had undergone sequential therapy with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) at 1 mg and developed sequential resistance and suboptimal viral suppression leading to treatment failure. Although tenofovir disoproxil fumarate (TDF) monotherapy was not able to result in complete virologic response (CVR), serum hepatitis B virus DNA levels were decreased to 85 IU/mL with a reduction of 3.9 IU/mL, accomplishing near CVR.