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Open-Access Journal
Editorial
Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question 
Letiția Adela Maria Streba, Cristin Constantin Vere, Ion Rogoveanu, Costin Teodor Streba 
World J Gastroenterol 21(14):4103-4110. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4103
Review
Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions 
Jeremy R Huddy, Melody Z Ni, Sheraz R Markar, George B Hanna 
World J Gastroenterol 21(14):4111-4120. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4111
Minireviews
Optimum chemotherapy for the management of advanced biliary tract cancer 
Marwan Ghosn, Hampig Raphael Kourie, Elie El Rassy, Ralph Chebib, Fadi El Karak, Colette Hanna, Dolly Nasr 
World J Gastroenterol 21(14):4121-4125. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4121
Basic Study
Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure 
Nicholas G Theodorakis, Yining N Wang, Vyacheslav A Korshunov, Mary A Maluccio, Nicholas J Skill 
World J Gastroenterol 21(14):4126-4135. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4126
Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases 
Jun-Xiao Zhang, Lei Fu, Richarda M de Voer, Marc-Manuel Hahn, Peng Jin, Chen-Xi Lv, Eugène TP Verwiel, Marjolijn JL Ligtenberg, Nicoline Hoogerbrugge, Roland P Kuiper, Jian-Qiu Sheng, Ad Geurts van Kessel 
World J Gastroenterol 21(14):4136-4149. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4136
Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery 
Susan Lapthorne, Julie E Bines, Fiona Fouhy, Nicole L Dellios, Guineva Wilson, Sarah L Thomas, Michelle Scurr, Catherine Stanton, Paul D Cotter, Prue M Pereira-Fantini 
World J Gastroenterol 21(14):4150-4158. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4150
Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury 
Donia Tabka, Mohamed Bejaoui, James Javellaud, Joan Roselló-Catafau, Jean-Michel Achard, Hassen Ben Abdennebi 
World J Gastroenterol 21(14):4159-4168. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4159
Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells 
Cheng-Chia Tsai, Tang-Wei Chuang, Li-Jen Chen, Ho-Shan Niu, Kun-Ming Chung, Juei-Tang Cheng, Kao-Chang Lin 
World J Gastroenterol 21(14):4169-4177. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4169
Anti-Helicobacter pylori activities of Chenopodium ambrosioides L. in vitro and in vivo 
Hui Ye, Yu Liu, Ning Li, Jing Yu, Hong Cheng, Jiang Li, Xue-Zhi Zhang 
World J Gastroenterol 21(14):4178-4183. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4178
Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury 
Wen-Ju Chang, Lu-Jun Song, Tuo Yi, Kun-Tang Shen, Hong-Shan Wang, Xiao-Dong Gao, Min Li, Jian-Min Xu, Wei-Xin Niu, Xin-Yu Qin 
World J Gastroenterol 21(14):4184-4194. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4184
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice 
Jing-Yao Zhang, Si-Dong Song, Qing Pang, Rui-Yao Zhang, Yong Wan, Da-Wei Yuan, Qi-Fei Wu, Chang Liu 
World J Gastroenterol 21(14):4195-4209. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4195
Multiphoton microscopy for tumor regression grading after neoadjuvant treatment for colorectal carcinoma 
Lian-Huang Li, Zhi-Fen Chen, Xing-Fu Wang, Shuang-Mu Zhuo, Hong-Sheng Li, Wei-Zhong Jiang, Guo-Xian Guan, Jian-Xin Chen 
World J Gastroenterol 21(14):4210-4215. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4210
Th22 cell accumulation is associated with colorectal cancer development 
Yong-Hong Huang, Yun-Fei Cao, Zhi-Yuan Jiang, Sen Zhang, Feng Gao 
World J Gastroenterol 21(14):4216-4224. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4216
Inhibitory effects of emodin, baicalin, schizandrin and berberine on hefA gene: Treatment of Helicobacter pylori-induced multidrug resistance 
Yan-Qiang Huang, Gan-Rong Huang, Ming-Hui Wu, Hua-Ying Tang, Zan-Song Huang, Xi-Han Zhou, Wen-Qiang Yu, Jian-Wei Su, Xiao-Qiang Mo, Bing-Pu Chen, Li-Juan Zhao, Xiao-Feng Huang, Hong-Yu Wei, Lian-Deng Wei 
World J Gastroenterol 21(14):4225-4231. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4225
Case Control Study
Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population 
Jia-Yan Yao, Kang Chao, Min-Rui Li, Yan-Qing Wu, Bi-Hui Zhong 
World J Gastroenterol 21(14):4232-4239. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4232
Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer 
Jin-Liang Zhang, Hui-Yun Wang, Qing Yang, Shi-Yong Lin, Guang-Yu Luo, Rong Zhang, Guo-Liang Xu 
World J Gastroenterol 21(14):4240-4247. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4240
Retrospective Study
Is cholecystectomy a reasonable treatment option for simple gallbladder polyps larger than 10 mm? 
Hye Yon Park, Se Hoon Oh, Kwang Hyuck Lee, Jong Kyun Lee, Kyu Taek Lee 
World J Gastroenterol 21(14):4248-4254. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4248
Correlation between metastatic lymph node ratio and prognosis in patients with extrahepatic cholangiocarcinoma 
Jian-Wei Zhang, Yun-Mian Chu, Zhong-Min Lan, Xiao-Long Tang, Ying-Tai Chen, Cheng-Feng Wang, Xu Che 
World J Gastroenterol 21(14):4255-4260. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4255
Biliary tract intraductal papillary mucinous neoplasm: Report of 19 cases 
Xing Wang, Yun-Qiang Cai, Yong-Hua Chen, Xu-Bao Liu 
World J Gastroenterol 21(14):4261-4267. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4261
Prospective Study
Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma 
Min-Young Lee, Ki Sun Jung, Hae Su Kim, Ji Yun Lee, Sung Hee Lim, Moonjin Kim, Hyun Ae Jung, Sung Min Kim, Jong Mu Sun, Myung-Ju Ahn, Jeeyun Lee, Se Hoon Park, Seong Yoon Yi, In Gyu Hwang, Sang-Cheol Lee, Hee Kyung Ahn, Do Hyoung Lim, Soon Il Lee, Keon Woo Park 
World J Gastroenterol 21(14):4268-4274. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4268
Preparation of magnetic resonance probes using one-pot method for detection of hepatocellular carcinoma 
You-Wei Li, Zheng-Guang Chen, Zhou-She Zhao, Hong-Li Li, Ji-Chen Wang, Zong-Ming Zhang 
World J Gastroenterol 21(14):4275-4283. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4275
Prophylactic antiviral therapy in allogeneic hematopoietic stem cell transplantation in hepatitis B virus patients 
Ya-Ping Liao, Jia-Lu Jiang, Wai-Yi Zou, Duo-Rong Xu, Juan Li 
World J Gastroenterol 21(14):4284-4292. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4284
Arpin contributes to bacterial translocation and development of severe acute pancreatitis 
Wen-Sheng Deng, Jian Zhang, Hui Ju, Hong-Mei Zheng, Jiang Wang, Su Wang, Dian-Liang Zhang 
World J Gastroenterol 21(14):4293-4301. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4293
Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life 
Xiao-Jun Yang, Hong-Mei Jiang, Xiao-Hua Hou, Jun Song 
World J Gastroenterol 21(14):4302-4309. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4302
Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients 
Kai Qu, Su-Shun Liu, Zhi-Xin Wang, Zi-Chao Huang, Si-Nan Liu, Hu-Lin Chang, Xin-Sen Xu, Ting Lin, Ya-Feng Dong, Chang Liu 
World J Gastroenterol 21(14):4310-4322. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4310
Systematic Reviews
Carbohydrate antigen 19-9 for differential diagnosis of pancreatic carcinoma and chronic pancreatitis 
Si-Biao Su, Shan-Yu Qin, Wen Chen, Wei Luo, Hai-Xing Jiang 
World J Gastroenterol 21(14):4323-4333. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4323
Meta-Analysis
Superparamagnetic iron oxide-enhanced magnetic resonance imaging for focal hepatic lesions: Systematic review and meta-analysis 
You-Wei Li, Zheng-Guang Chen, Ji-Chen Wang, Zong-Ming Zhang 
World J Gastroenterol 21(14):4334-4344. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4334
Probiotics in Helicobacter pylori eradication therapy: A systematic review and meta-analysis 
Min-Min Zhang, Wei Qian, Ying-Yi Qin, Jia He, Yu-Hao Zhou 
World J Gastroenterol 21(14):4345-4357. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4345
Efficacy of S-1 vs capecitabine for the treatment of gastric cancer: A meta-analysis 
An-Bing He, Xiu-Lan Peng, Jia Song, Ji-Xing Zhang, Wei-Guo Dong, Ren-Feng Luo, Yan Tang 
World J Gastroenterol 21(14):4358-4364. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4358
Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis 
Qi-Bin Song, Qi Wang, Wei-Guo Hu 
World J Gastroenterol 21(14):4365-4372. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4365
Case Report
Ipilimumab associated colitis: An IpiColitis case series at MedStar Georgetown University Hospital 
Pawan Rastogi, Mohamed Sultan, Aline J Charabaty, Michael B Atkins, Mark C Mattar 
World J Gastroenterol 21(14):4373-4378. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4373
Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with Crohn’s disease 
Andrea Taddio, Alberto Tommasini, Erica Valencic, Ettore Biagi, Giuliana Decorti, Sara De Iudicibus, Eva Cuzzoni, Giuseppe Gaipa, Raffaela Badolato, Alberto Prandini, Andrea Biondi, Alessandro Ventura 
World J Gastroenterol 21(14):4379-4384. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4379
Fatal submucosal invasive gastric adenosquamous carcinoma detected at surveillance after gastric endoscopic submucosal dissection 
Akinori Shirahige, Haruhisa Suzuki, Ichiro Oda, Masau Sekiguchi, Genki Mori, Seiichiro Abe, Satoru Nonaka, Shigetaka Yoshinaga, Shigeki Sekine, Ryoji Kushima, Yutaka Saito, Takeo Fukagawa, Hitoshi Katai 
World J Gastroenterol 21(14):4385-4390. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4385
Myoepithelial carcinoma of the stomach: A diagnostic pitfall 
Chih-En Tseng, Yu-Hsi Hsieh, Chang-Kuo Wei, Hsuan-Ying Huang, Chen-Lin Chi 
World J Gastroenterol 21(14):4391-4396. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4391
Clostridium perfringens infection after transarterial chemoembolization for large hepatocellular carcinoma 
Jing-Huan Li, Rong-Rong Yao, Hu-Jia Shen, Lan Zhang, Xiao-Ying Xie, Rong-Xin Chen, Yan-Hong Wang, Zheng-Gang Ren 
World J Gastroenterol 21(14):4397-4401. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4397
Secondary acute promyelocytic leukemia following chemotherapy for gastric cancer: A case report 
Ying-Cheng Zhang, Yu-Qi Zhou, Bing Yan, Jun Shi, Li-Juan Xiu, Yu-Wei Sun, Xuan Liu, Zhi-Feng Qin, Pin-Kang Wei, Yong-Jin Li 
World J Gastroenterol 21(14):4402-4407. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4402
Mesorectum localization as a special kind of rectal metastasis from breast cancer 
Fan Xue, Zhong-Lin Liu, Qing Zhang, Xiang-Nan Kong, Wen-Zhi Liu 
World J Gastroenterol 21(14):4408-4412. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4408
Laparoscope resection of retroperitoneal ectopic insulinoma: A rare case 
Jie Liu, Cheng-Wu Zhang, De-Fei Hong, Jia Wu, Hong-Guo Yang, Yuan Chen, Da-Jian Zhao, Yu-Hua Zhang 
World J Gastroenterol 21(14):4413-4418. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4413
Collagenous nodule mixed simple cyst and hemangioma coexistence in the liver 
Zhen-Jiang Zheng, Shu Zhang, Yang Cao, Guang-Chun Pu, Hong Liu 
World J Gastroenterol 21(14):4419-4422. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4419
Letters To The Editor
Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients 
Aiman Obed, Steffen Stern, Anwar Jarrad, Thomas Lorf 
World J Gastroenterol 21(14):4423-4426. Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4423