Tseng CE, Hsieh YH, Wei CK, Huang HY, Chi CL. Myoepithelial carcinoma of the stomach: A diagnostic pitfall. World J Gastroenterol 2015; 21(14): 4391-4396 [PMID: 25892892 DOI: 10.3748/wjg.v21.i14.4391]
Corresponding Author of This Article
Dr. Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzuchi Hospital, No. 2 Minsheng Road, Dalin Township, Chiayi 62247, Taiwan. dm360385@tzuchi.com.tw
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 14, 2015; 21(14): 4391-4396 Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4391
Myoepithelial carcinoma of the stomach: A diagnostic pitfall
Chih-En Tseng, Yu-Hsi Hsieh, Chang-Kuo Wei, Hsuan-Ying Huang, Chen-Lin Chi
Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan
Chih-En Tseng, Yu-Hsi Hsieh, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
Yu-Hsi Hsieh, Department of Gastroenterology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan
Chang-Kuo Wei, Department of General Surgery, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan
Hsuan-Ying Huang, Department of Anatomical Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
Author contributions: Hsieh YH and Wei CK provided the case and the clinical information; Tseng CE and Chi CL contributed to the artwork and pathological diagnosis; Huang HY, as the consultant, provided the molecular test for this case and confirmed the diagnosis.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzuchi Hospital, No. 2 Minsheng Road, Dalin Township, Chiayi 62247, Taiwan. dm360385@tzuchi.com.tw
Received: August 19, 2014 Peer-review started: August 20, 2014 First decision: September 27, 2014 Revised: October 20, 2014 Accepted: December 16, 2014 Article in press: December 16, 2014 Published online: April 14, 2015
Abstract
Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral sites. This report describes a case of a rare low-grade myoepithelial carcinoma of the stomach. A 61-year-old female patient presented with postprandial abdominal discomfort. Endoscopy revealed a 1.1 cm submucosal lesion. Local excision was performed after malignancy was confirmed by biopsy. The resection margin is free of tumor and she received no adjuvant therapy. The tumor was characterized by multinodular growth with biphasic epithelioid and spindle components. Infiltrative margin and nuclear pleomorphism are seen. Tumor cells were positive for both epithelial and myoepithelial markers. Evidence of epithelial differentiation was confirmed by electron microscopy. No EWSR1 rearrangement was detected. The final diagnosis was low-grade myoepithelial gastric carcinoma. The patient is currently well, and no evidence of recurrence or metastasis was found after ten-month of follow-up. Myoepithelial carcinoma should be considered in the differential diagnosis of a biphasic gastric tumor.
Core tip: Myoepithelial tumor can cause diagnostic pitfall due to its rarity and various morphology. This report reveals a rare low-grade myoepithelial carcinoma of stomach and its morphological, immunohistochemical and molecular characteristics.
