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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4103-4110
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4103
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4103
Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question
Letiția Adela Maria Streba, Internal Medicine, Medical Semiology, University of Medicine and Pharmacy of Craiova, 200639 Craiova, Romania
Cristin Constantin Vere, Ion Rogoveanu, Costin Teodor Streba, Research Center of Gastroenterology and Hepatology of Craiova, University of Medicine and Pharmacy of Craiova, 200639 Craiova, Romania
Cristin Constantin Vere, Ion Rogoveanu, Internal Medicine, Gastroenterology, University of Medicine and Pharmacy of Craiova, 200639 Craiova, Romania
Author contributions: Streba LAM, Vere CC, and Rogoveanu I contributed equally to this manuscript and share first authorship; Streba LAM and Vere CC wrote this paper; Rogoveanu I and Streba CT performed the literature search and critically revised the text.
Supported by Grant from European Social Found, Human Resources Development Operational Programme 2007-2013, No. POSDRU/159/1.5/133377.
Conflict-of-interest: The authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Costin Teodor Streba, MD, PhD, MSc, Research Center of Gastroenterology and Hepatology of Craiova, University of Medicine and Pharmacyof Craiova, 1 Mai 66, 200639 Craiova, Romania. costinstreba@gmail.com
Telephone: +40-722-389906 Fax: +40-351-401376
Received: November 29, 2014
Peer-review started: November 29, 2014
First decision: December 26, 2014
Revised: January 17, 2015
Accepted: February 13, 2015
Article in press: February 13, 2015
Published online: April 14, 2015
Peer-review started: November 29, 2014
First decision: December 26, 2014
Revised: January 17, 2015
Accepted: February 13, 2015
Article in press: February 13, 2015
Published online: April 14, 2015
Core Tip
Core tip: Nonalcoholic liver disease (NAFLD) comprises both simple steatosis or nonalcoholic fatty liver and nonalcoholic steatohepatitis, with or without cirrhosis. Recent data demonstrate a strong association between most features of metabolic syndrome and NAFLD. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, for which current epidemiologic data show an increased incidence in NAFLD patients. Basic research has identified pathways linking obesity, type 2 diabetes, systemic inflammation, NAFLD/nonalcoholic steatohepatitis, and HCC. However, more data are necessary in order to effectively establish these relationships, and perhaps pave the way for possible cures to prevent HCC in certain populations.