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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2015; 21(14): 4275-4283
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4275
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4275
Preparation of magnetic resonance probes using one-pot method for detection of hepatocellular carcinoma
You-Wei Li, Department of Radiology, Beijing Chuiyangliu Hospital Affiliated to School of Medicine, Tsinghua University, Beijing 100022, China
Zheng-Guang Chen, Department of Radiology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
Zhou-She Zhao, Hong-Li Li, GE Healthcare China, Beijing Economic and Technology Development Area, Beijing 100176, China
Ji-Chen Wang, Department of Radiology, Nanjing BenQ Hospital, Nanjing 210036, Jiangsu Province, China
Zong-Ming Zhang, Department of General Surgery, Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, China
Author contributions: Zhang ZM and Zhao ZS designed the study; Li YW, Chen ZG and Li HL performed the study; Wang JC provided analytic tools and analyzed the data; Li YW and Chen ZG wrote the paper.
Supported by National Natural Science Foundation of China, No. 81071996.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zong-Ming Zhang, MD, PhD, Professor, Director, Department of General Surgery, Beijing Electric Power Hospital, Capital Medical University, No. 1 Taipingqiaoxili, Fengtai District, Beijing 100073, China. zhangzongming@mail.tsinghua.edu.cn
Telephone: +86-10-63503046 Fax: +86-10-63465865
Received: August 20, 2014
Peer-review started: August 20, 2014
First decision: November 4, 2014
Revised: November 17, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: April 14, 2015
Peer-review started: August 20, 2014
First decision: November 4, 2014
Revised: November 17, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: April 14, 2015
Core Tip
Core tip: The preparation process of magnetic resonance probes should be as simple as possible in order to have mass production. We developed a method named one-pot method by modifying the traditional methods to prepare an anti-glypican 3-ultrasmall superparamagnetic iron oxide nanoparticle (USPION) probe and an anti-α-fetoprotein-USPION probe and determined their physical and chemical properties and bioactivity. The results showed that this method is simple and convenient to synthesize the magnetic resonance molecular probes. The synthesized probes entered into the specific cells in vitro.