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Topic Highlight
Hepatitis C virus in the new era: Perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy 
Filippo Ansaldi, Andrea Orsi, Laura Sticchi, Bianca Bruzzone, Giancarlo Icardi 
World J Gastroenterol 20(29):9633-9652. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9633
Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells 
Elizabeth R Mann, Xuhang Li 
World J Gastroenterol 20(29):9653-9664. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9653
Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis 
Imerio Angriman, Marco Scarpa, Ignazio Castagliuolo 
World J Gastroenterol 20(29):9665-9674. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9665
Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease 
Sara Renna, Mario Cottone, Ambrogio Orlando 
World J Gastroenterol 20(29):9675-9690. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9675
Preventing infective complications in inflammatory bowel disease 
Justine Mill, Ian C Lawrance 
World J Gastroenterol 20(29):9691-9698. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9691
Treating inflammatory bowel disease by adsorptive leucocytapheresis: A desire to treat without drugs 
Abbi R Saniabadi, Tomotaka Tanaka, Toshihide Ohmori, Koji Sawada, Takayuki Yamamoto, Hiroyuki Hanai 
World J Gastroenterol 20(29):9699-9715. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9699
Inflammatory pathways in the early steps of colorectal cancer development 
Francesco Mariani, Paola Sena, Luca Roncucci 
World J Gastroenterol 20(29):9716-9731. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9716
Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer 
Alfonso De Stefano, Chiara Carlomagno 
World J Gastroenterol 20(29):9732-9743. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9732
p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance 
Valentina Grossi, Alessia Peserico, Tugsan Tezil, Cristiano Simone 
World J Gastroenterol 20(29):9744-9758. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9744
Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer 
Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Elżbieta Grochowska-Niedworok, Dariusz Waniczek, Janusz Wierzgoń 
World J Gastroenterol 20(29):9759-9774. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9759
Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years 
Mariusz Panczyk 
World J Gastroenterol 20(29):9775-9827. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9775
Genetic predisposition to colorectal cancer: Where we stand and future perspectives 
Laura Valle 
World J Gastroenterol 20(29):9828-9849. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9828
Controversies in the pathological assessment of colorectal cancer 
Aoife Maguire, Kieran Sheahan 
World J Gastroenterol 20(29):9850-9861. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9850
Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer 
Woo-Jeong Jeong, Pu-Hyeon Cha, Kang-Yell Choi 
World J Gastroenterol 20(29):9862-9871. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9862
Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis 
Eun Ran Kim, Dong Kyung Chang 
World J Gastroenterol 20(29):9872-9881. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9872
Structural modifications of Helicobacter pylori lipopolysaccharide: An idea for how to live in peace 
Magdalena Chmiela, Eliza Miszczyk, Karolina Rudnicka 
World J Gastroenterol 20(29):9882-9897. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9882
Treatment of Helicobacter pylori infection: Meeting the challenge of antimicrobial resistance 
Vasilios Papastergiou, Sotirios D Georgopoulos, Stylianos Karatapanis 
World J Gastroenterol 20(29):9898-9911. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9898
Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance 
Sinéad M Smith, Colm O’Morain, Deirdre McNamara 
World J Gastroenterol 20(29):9912-9921. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9912
Helicobacter pylori and oral pathology: Relationship with the gastric infection 
Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Boris Elsner, Alejandra Avagnina, Valeria Denninghoff 
World J Gastroenterol 20(29):9922-9935. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9922
Surgical management of peritonitis secondary to acute superior mesenteric artery occlusion 
Stefan Acosta 
World J Gastroenterol 20(29):9936-9941. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9936
Review
Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance 
Mohtashem Samsam, Raheleh Ahangari, Saleh A Naser 
World J Gastroenterol 20(29):9942-9951. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9942
Therapeutic uses of animal biles in traditional Chinese medicine: An ethnopharmacological, biophysical chemical and medicinal review 
David Q-H Wang, Martin C Carey 
World J Gastroenterol 20(29):9952-9975. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9952
Endoscopic ultrasound in the diagnosis and treatment of pancreatic disease 
Christopher W Teshima, Gurpal S Sandha 
World J Gastroenterol 20(29):9976-9989. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9976
Spontaneous free perforation of the small intestine in adults 
Hugh James Freeman 
World J Gastroenterol 20(29):9990-9997. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9990
Liver metastases: Contrast-enhanced ultrasound compared with computed tomography and magnetic resonance 
Vito Cantisani, Hektor Grazhdani, Cristina Fioravanti, Maria Rosignuolo, Fabrizio Calliada, Daniela Messineo, Maria Giulia Bernieri, Adriano Redler, Carlo Catalano, Ferdinando D’Ambrosio 
World J Gastroenterol 20(29):9998-10007. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9998
Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas 
Marina Paini, Stefano Crippa, Stefano Partelli, Filippo Scopelliti, Domenico Tamburrino, Andrea Baldoni, Massimo Falconi 
World J Gastroenterol 20(29):10008-10023. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10008
Capsule endoscopy: Present status and future expectation 
Mahesh K Goenka, Shounak Majumder, Usha Goenka 
World J Gastroenterol 20(29):10024-10037. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10024
Original Article
Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells 
Matilde Spampatti, George Vlotides, Gerald Spöttl, Julian Maurer, Burkhard Göke, Christoph J Auernhammer 
World J Gastroenterol 20(29):10038-10049. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10038
IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions 
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino, Yasuhisa Shinomura 
World J Gastroenterol 20(29):10050-10061. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10050
CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation 
Hui-Hong Zhai, Juan Meng, Jing-Bo Wang, Zhen-Xiong Liu, Yuan-Fei Li, Shan-Shan Feng 
World J Gastroenterol 20(29):10062-10070. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10062
KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients 
Shao-Qin Chen, Zhi-Hua Chen, Su-Yong Lin, Qi-Bao Dai, Leng-Xi Fu, Rui-Qing Chen 
World J Gastroenterol 20(29):10071-10081. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10071
Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression 
Qing-Yu Zhang, Ran Li, Guo-Fang Zeng, Bin Liu, Jie Liu, Yang Shu, Zhong-Kao Liu, Zhi-Dong Qiu, Dong-Jun Wang, Hui-Lai Miao, Ming-Yi Li, Run-Zhi Zhu 
World J Gastroenterol 20(29):10082-10093. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10082
RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer 
Wei-Ling He, Yu-Huang Li, Wei-Jian Hou, Zun-Fu Ke, Xin-Lin Chen, Li-Ya Lu, Shi-Rong Cai, Wu Song, Chang-Hua Zhang, Yu-Long He 
World J Gastroenterol 20(29):10094-10107. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10094
Evidence-Based Medicine
Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease 
Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Kento Imajo, Yoshio Sumida, Yuichiro Eguchi, Hideki Fujii, Hideyuki Hyogo, Masafumi Ono, Yasuaki Suzuki, Takumi Kawaguchi, Kazuaki Chayama, Saiyu Tanaka, Kazuma Fujimoto, Keizo Anzai, Toshiji Saibara, Michio Sata, Yoshito Itoh, Atsushi Nakajima, Takeshi Okanoue; Japan Study Group of NAFLD (JSG-NAFLD) 
World J Gastroenterol 20(29):10108-10114. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10108
Retrospective Study
Surgical management of colonic diverticular disease: Discrepancy between right- and left-sided diseases 
Heung-Kwon Oh, Eon Chul Han, Heon-Kyun Ha, Eun Kyung Choe, Sang Hui Moon, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park 
World J Gastroenterol 20(29):10115-10120. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10115
Using cholecystokinin to facilitate endoscopic clearance of large common bile duct stones 
Tao Tao, Qi-Jie Zhang, Ming Zhang, Xiao Zhu, Shu-Xia Sun, Yan-Qing Li 
World J Gastroenterol 20(29):10121-10127. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10121
Observational Study
Physical activity support or weight loss counseling for nonalcoholic fatty liver disease? 
Luca Montesi, Chiara Caselli, Elena Centis, Chiara Nuccitelli, Simona Moscatiello, Alessandro Suppini, Giulio Marchesini 
World J Gastroenterol 20(29):10128-10136. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10128
Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review 
Dolores Ayllon Teran, Oscar Gómez Beltran, Rubén Ciria Bru, Elena Mateos González, María José Peña Rosa, Antonio Luque Molina, Pedro López Cillero, Javier Briceño Delgado 
World J Gastroenterol 20(29):10137-10143. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10137
Prospective Study
Trends in incidence and management of cancer of the ampulla of Vater 
Florian Rostain, Samia Hamza, Antoine Drouillard, Jean Faivre, Anne-Marie Bouvier, Côme Lepage 
World J Gastroenterol 20(29):10144-10150. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10144
Randomized Controlled Trial
Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis? 
Zoltán Döbrönte, Zoltán Szepes, Ferenc Izbéki, Judit Gervain, László Lakatos, Gyula Pécsi, Miklós Ihász, Lilla Lakner, Erzsébet Toldy, László Czakó 
World J Gastroenterol 20(29):10151-10157. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10151
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats 
Sami Akbulut, Hulya Elbe, Cengiz Eris, Zumrut Dogan, Gulten Toprak, Emrah Otan, Erman Erdemli, Yusuf Turkoz 
World J Gastroenterol 20(29):10158-10165. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158
Meta-Analysis
Pouch size influences clinical outcome of pouch construction after total gastrectomy: A meta-analysis 
Heng-Lei Dong, Yu-Bei Huang, Xue-Wei Ding, Feng-Ju Song, Ke-Xin Chen, Xi-Shan Hao 
World J Gastroenterol 20(29):10166-10173. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10166
Clinical outcome of small hepatocellular carcinoma after different treatments: A meta-analysis 
Wei Dong, Ting Zhang, Zhen-Guang Wang, Hui Liu 
World J Gastroenterol 20(29):10174-10182. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10174
Transthoracic vs transhiatal surgery for cancer of the esophagogastric junction: A meta-analysis 
Ming-Tian Wei, Yuan-Chuan Zhang, Xiang-Bing Deng, Ting-Han Yang, Ya-Zhou He, Zi-Qiang Wang 
World J Gastroenterol 20(29):10183-10192. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10183
Case Report
Fever as a first manifestation of advanced gastric adenosquamous carcinoma: A case report 
Harsha Ajoodhea, Ren-Chao Zhang, Xiao-Wu Xu, Wei-Wei Jin, Ke Chen, Yong-Tao He, Yi-Ping Mou 
World J Gastroenterol 20(29):10193-10201. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10193
Imaging findings of primary gastric plasmacytoma: A case report 
Zhen-Hua Zhao, Jian-Feng Yang, Jin-Dao Wang, Jian-Guo Wei, Fang Liu, Bo-Yin Wang 
World J Gastroenterol 20(29):10202-10207. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10202
Little girl who conquered the "ALPPS'' 
Albert Chan, Patrick HY Chung, Ronnie TP Poon 
World J Gastroenterol 20(29):10208-10211. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10208
Letters To The Editor
E2F transcription factors and digestive system malignancies: How much do we know? 
Konstantinos Evangelou, Sophia Havaki, Athanassios Kotsinas 
World J Gastroenterol 20(29):10212-10216. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10212
Cannulation of the intradiverticular papilla using a duodenoscope: Is it a safe method? 
Yun Qian, Jin Huang, Yin Zhang, Zhi-Ning Fan 
World J Gastroenterol 20(29):10217-10218. Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10217