Smith SM, O’Morain C, McNamara D. Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance. World J Gastroenterol 2014; 20(29): 9912-9921 [PMID: 25110421 DOI: 10.3748/wjg.v20.i29.9912]
Corresponding Author of This Article
Sinéad M Smith, PhD, Assistant Professor in Applied and Translational Medicine, Department of Clinical Medicine, Trinity College Dublin, Trinity Centre, Adelaide and Meath Hospital, Room 1.44, Tallaght, Dublin 24, Ireland. smithsi@tcd.ie
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. Aug 7, 2014; 20(29): 9912-9921 Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9912
Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance
Sinéad M Smith, Colm O’Morain, Deirdre McNamara
Sinéad M Smith, Colm O’Morain, Deirdre McNamara, Department of Clinical Medicine, Trinity College Dublin, Trinity Centre, Adelaide and Meath Hospital, Dublin 24, Ireland
Sinéad M Smith, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland
Deirdre McNamara, Department of Gastroenterology, Adelaide and Meath Hospital, Dublin 24, Ireland
Author contributions: Smith SM reviewed the literature, drafted and wrote the manuscript; O’Morain C and McNamara D critically reviewed the manuscript and provided intellectual input; all authors approved the manuscript for publication.
Supported by The Meath Foundation
Correspondence to: Sinéad M Smith, PhD, Assistant Professor in Applied and Translational Medicine, Department of Clinical Medicine, Trinity College Dublin, Trinity Centre, Adelaide and Meath Hospital, Room 1.44, Tallaght, Dublin 24, Ireland. smithsi@tcd.ie
Telephone: +353-1-8962998 Fax: +353-1-8962988
Received: October 17, 2013 Revised: February 13, 2014 Accepted: April 27, 2014 Published online: August 7, 2014
Core Tip
Core tip: There has been a significant decrease in the success rate of empirical triple therapy to treat Helicobacter pylori (H. pylori) infection, largely due to a rapid increase in the prevalence of antibiotic resistant strains. Antibiotic resistance is a constantly evolving process and there are significant regional variations in H. pylori antibiotic resistance rates. As such, local surveillance of antibiotic resistance is warranted to guide clinicians in their therapeutic choice. Standard culture-based antimicrobial susceptibility testing and molecular methods provide key opportunities to tailor H. pylori treatment based on the detection of antibiotic resistant strains, thereby enhancing eradication rates and decreasing H. pylori-associated disease.
