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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Update on the treatment of type 2 diabetes mellitus  
Juan José Marín-Peñalver, Iciar Martín-Timón, Cristina Sevillano-Collantes, Francisco Javier del Cañizo-Gómez 
World J Diabetes 7(17):354-395. Published online Sep 15, 2016. doi: 10.4239/wjd.v7.i17.354
2
Literature review on the management of diabetic foot ulcer  
Leila Yazdanpanah, Morteza Nasiri, Sara Adarvishi 
World J Diabetes 6(1):37-53. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.37
3
Short acting insulin analogues in intensive care unit patients  
Federico Bilotta, Carolina Guerra, Rafael Badenes, Simona Lolli, Giovanni Rosa 
World J Diabetes 5(3):230-234. Published online Jun 15, 2014. doi: 10.4239/wjd.v5.i3.230
4
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus  
Surapon Tangvarasittichai 
World J Diabetes 6(3):456-480. Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.456
5
6
Adiponectin: Probe of the molecular paradigm associating diabetes and obesity  
Kakali Ghoshal, Maitree Bhattacharyya 
World J Diabetes 6(1):151-166. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.151
7
Role of vitamin D in diabetes mellitus and chronic kidney disease  
Akio Nakashima, Keitaro Yokoyama, Takashi Yokoo, Mitsuyoshi Urashima 
World J Diabetes 7(5):89-100. Published online Mar 10, 2016. doi: 10.4239/wjd.v7.i5.89
8
Diabetic foot disease: From the evaluation of the “foot at risk” to the novel diabetic ulcer treatment modalities  
Noha Amin, John Doupis 
World J Diabetes 7(7):153-164. Published online Apr 10, 2016. doi: 10.4239/wjd.v7.i7.153
9
Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?  
Iciar Martín-Timón, Cristina Sevillano-Collantes, Amparo Segura-Galindo, Francisco Javier del Cañizo-Gómez 
World J Diabetes 5(4):444-470. Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.444
10
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide  
Emanuel Monteiro Candeias, Inês Carolina Sebastião, Susana Maria Cardoso, Sónia Catarina Correia, Cristina Isabel Carvalho, Ana Isabel Plácido, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira, Ana Isabel Duarte 
World J Diabetes 6(6):807-827. Published online Jun 25, 2015. doi: 10.4239/wjd.v6.i6.807
11
Milestones in the history of diabetes mellitus: The main contributors  
Marianna Karamanou, Athanase Protogerou, Gregory Tsoucalas, George Androutsos, Effie Poulakou-Rebelakou 
World J Diabetes 7(1):1-7. Published online Jan 10, 2016. doi: 10.4239/wjd.v7.i1.1
12
Molecular and biochemical trajectories from diabetes to Alzheimer’s disease: A critical appraisal  
Rajat Sandhir, Smriti Gupta 
World J Diabetes 6(12):1223-1242. Published online Sep 25, 2015. doi: 10.4239/wjd.v6.i12.1223
13
Leucine signaling in the pathogenesis of type 2 diabetes and obesity  
Bodo C Melnik 
World J Diabetes 3(3):38-53. Published online Mar 15, 2012. doi: 10.4239/wjd.v3.i3.38
14
Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome  
Juan Antonio Paniagua 
World J Diabetes 7(19):483-514. Published online Nov 15, 2016. doi: 10.4239/wjd.v7.i19.483
15
Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research  
Benjamin M Leon, Thomas M Maddox 
World J Diabetes 6(13):1246-1258. Published online Oct 10, 2015. doi: 10.4239/wjd.v6.i13.1246
16
Role of bile acids in the regulation of the metabolic pathways  
Hiroki Taoka, Yoko Yokoyama, Kohkichi Morimoto, Naho Kitamura, Tatsuya Tanigaki, Yoko Takashina, Kazuo Tsubota, Mitsuhiro Watanabe 
World J Diabetes 7(13):260-270. Published online Jul 10, 2016. doi: 10.4239/wjd.v7.i13.260
17
18
Psychological aspects of diabetes care: Effecting behavioral change in patients  
Boon-How Chew, Sazlina Shariff-Ghazali, Aaron Fernandez 
World J Diabetes 5(6):796-808. Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.796
19
Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures  
Bipradas Roy 
World J Diabetes 4(4):101-113. Published online Aug 15, 2013. doi: 10.4239/wjd.v4.i4.101
20
Relationship between diabetes and periodontal infection  
Fernando Llambés, Santiago Arias-Herrera, Raúl Caffesse 
World J Diabetes 6(7):927-935. Published online Jul 10, 2015. doi: 10.4239/wjd.v6.i7.927
21
Trends in prevalence of diabetes in Asian countries  
Ambady Ramachandran, Chamukuttan Snehalatha, Ananth Samith Shetty, Arun Nanditha 
World J Diabetes 3(6):110-117. Published online Jun 15, 2012. doi: 10.4239/wjd.v3.i6.110
22
Gestational diabetes: A clinical update  
Ulla Kampmann, Lene Ring Madsen, Gitte Oeskov Skajaa, Ditte Smed Iversen, Niels Moeller, Per Ovesen 
World J Diabetes 6(8):1065-1072. Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1065
23
Whey protein: The “whey” forward for treatment of type 2 diabetes?  
Linda E Mignone, Tongzhi Wu, Michael Horowitz, Christopher K Rayner 
World J Diabetes 6(14):1274-1284. Published online Oct 25, 2015. doi: 10.4239/wjd.v6.i14.1274
24
Diabetic retinopathy - ocular complications of diabetes mellitus  
Martin M Nentwich, Michael W Ulbig 
World J Diabetes 6(3):489-499. Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.489
25
Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study  
Terra G Arnason, Matthew W Bowen, Kerry D Mansell 
World J Diabetes 8(4):154-164. Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.154
26
Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: A narrative review  
Héctor Eloy Tamez-Pérez, Dania Lizet Quintanilla-Flores, René Rodríguez-Gutiérrez, José Gerardo González-González, Alejandra Lorena Tamez-Peña 
World J Diabetes 6(8):1073-1081. Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1073
27
Diabetic neuropathic pain: Physiopathology and treatment  
Anne K Schreiber, Carina FM Nones, Renata C Reis, Juliana G Chichorro, Joice M Cunha 
World J Diabetes 6(3):432-444. Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.432
28
29
30
Cardiac autonomic neuropathy in patients with diabetes mellitus  
Gerasimos Dimitropoulos, Abd A Tahrani, Martin J Stevens 
World J Diabetes 5(1):17-39. Published online Feb 15, 2014. doi: 10.4239/wjd.v5.i1.17
31
Interpretation of cardiovascular outcome trials in type 2 diabetes needs a multiaxial approach  
Odd Erik Johansen 
World J Diabetes 6(9):1092-1096. Published online Aug 10, 2015. doi: 10.4239/wjd.v6.i9.1092
32
Social determinants of type 2 diabetes and health in the United States  
Myra L Clark, Sharon W Utz 
World J Diabetes 5(3):296-304. Published online Jun 15, 2014. doi: 10.4239/wjd.v5.i3.296
33
Causative anti-diabetic drugs and the underlying clinical factors for hypoglycemia in patients with diabetes  
Hidekatsu Yanai, Hiroki Adachi, Hisayuki Katsuyama, Sumie Moriyama, Hidetaka Hamasaki, Akahito Sako 
World J Diabetes 6(1):30-36. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.30
34
Gestational diabetes mellitus: Challenges for different ethnic groups  
Lili Yuen, Vincent W Wong 
World J Diabetes 6(8):1024-1032. Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1024
35
Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy  
Desirée Luis-Rodríguez, Alberto Martínez-Castelao, José Luis Górriz, Fernando de Álvaro, Juan F Navarro-González 
World J Diabetes 3(1):7-18. Published online Jan 15, 2012. doi: 10.4239/wjd.v3.i1.7
36
β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes  
Yoshifumi Saisho 
World J Diabetes 6(1):109-124. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.109
37
38
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition  
Iqra Hameed, Shariq R Masoodi, Shahnaz A Mir, Mudasar Nabi, Khalid Ghazanfar, Bashir A Ganai 
World J Diabetes 6(4):598-612. Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.598
39
Pharmacogenetic studies update in type 2 diabetes mellitus  
Shalini Singh, Kauser Usman, Monisha Banerjee 
World J Diabetes 7(15):302-315. Published online Aug 10, 2016. doi: 10.4239/wjd.v7.i15.302
40
Hyporeninemic hypoaldosteronism and diabetes mellitus: Pathophysiology assumptions, clinical aspects and implications for management  
André Gustavo P Sousa, João Victor de Sousa Cabral, William Batah El-Feghaly, Luísa Silva de Sousa, Adriana Bezerra Nunes 
World J Diabetes 7(5):101-111. Published online Mar 10, 2016. doi: 10.4239/wjd.v7.i5.101
41
Management of diabolical diabetes mellitus and periodontitis nexus: Are we doing enough?  
Abhijit N Gurav 
World J Diabetes 7(4):50-66. Published online Feb 25, 2016. doi: 10.4239/wjd.v7.i4.50
42
Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy  
Antonio Desmond McCarthy, Ana María Cortizo, Claudia Sedlinsky 
World J Diabetes 7(6):122-133. Published online Mar 25, 2016. doi: 10.4239/wjd.v7.i6.122
43
Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity  
Ananthi Anandhakrishnan, Márta Korbonits 
World J Diabetes 7(20):572-598. Published online Dec 15, 2016. doi: 10.4239/wjd.v7.i20.572
44
Respiratory failure in diabetic ketoacidosis  
Nikifor K Konstantinov, Mark Rohrscheib, Emmanuel I Agaba, Richard I Dorin, Glen H Murata, Antonios H Tzamaloukas 
World J Diabetes 6(8):1009-1023. Published online Jul 25, 2015. doi: 10.4239/wjd.v6.i8.1009
45
Counterregulation of insulin by leptin as key component of autonomic regulation of body weight  
Katarina T Borer 
World J Diabetes 5(5):606-629. Published online Oct 15, 2014. doi: 10.4239/wjd.v5.i5.606
46
Economic development and diabetes prevalence in MENA countries: Egypt and Saudi Arabia comparison  
Shalaby Sherif, Bauer E Sumpio 
World J Diabetes 6(2):304-311. Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.304
47
Type 2 diabetes mellitus in children and adolescents  
Thomas Reinehr 
World J Diabetes 4(6):270-281. Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.270
48
Treatment of prediabetes  
Mustafa Kanat, Ralph A DeFronzo, Muhammad A Abdul-Ghani 
World J Diabetes 6(12):1207-1222. Published online Sep 25, 2015. doi: 10.4239/wjd.v6.i12.1207
49
Type 2 diabetes and quality of life  
Aikaterini Trikkalinou, Athanasia K Papazafiropoulou, Andreas Melidonis 
World J Diabetes 8(4):120-129. Published online Apr 15, 2017. doi: 10.4239/wjd.v8.i4.120
50
Statin use and cognitive function in middle-aged adults with type 1 diabetes  
Karen A Nunley, Trevor J Orchard, Christopher M Ryan, Rachel Miller, Tina Costacou, Caterina Rosano 
World J Diabetes 8(6):286-296. Published online Jun 15, 2017. doi: 10.4239/wjd.v8.i6.286