Published online Jan 15, 2018. doi: 10.4239/wjd.v9.i1.1
Peer-review started: October 29, 2017
First decision: November 23, 2017
Revised: December 9, 2017
Accepted: December 29, 2017
Article in press: December 29, 2017
Published online: January 15, 2018
Core tip: Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus, which is strongly associated with increased risk of cardiovascular mortality. Although it is common complication, the significance of CAN has not been fully appreciated and there are no unified treatment algorithms for today. In this review we have analyzed the existing data about the known risk factors, screening and diagnostic algorithm, staging of CAN and possible treatment, including effectiveness of lifestyle modification, intensive glycemic control; treatment of diabetic dyslipidemia; antioxidants; vitamins; correction of vascular endothelial dysfunction; prevention and treatment of thrombosis; treatment of orthostatic hypotension.