Published online Aug 25, 2015. doi: 10.4239/wjd.v6.i10.1152
Peer-review started: April 18, 2015
First decision: May 13, 2015
Revised: June 29, 2015
Accepted: August 16, 2015
Article in press: August 17, 2015
Published online: August 25, 2015
Core tip: Diabetes is frequently associated with Mg deficit. The fact that most but not all diabetic subjects have low magnesium (Mg) and that no large randomised controlled trial (RCT) has been specifically focused on subjects with Mg deficit, diagnosed with a reliable technique, may help explain discrepancies of the role of supplemental Mg on glycemic control, and the impact on diabetes risk in prospective epidemiological studies. Different baseline Mg, metabolic control, and age are other potential factors that may contribute. Future prospective RCTs are needed to support the potential role of dietary Mg supplementation as a possible public health strategy to reduce diabetes risk in the population.