Published online Nov 15, 2018. doi: 10.4239/wjd.v9.i11.199
Peer-review started: July 22, 2018
First decision: August 9, 2018
Revised: August 30, 2018
Accepted: October 9, 2018
Article in press: October 9, 2018
Published online: November 15, 2018
Core tip: Serial arterial blood gas measurements and intravenous sodium bicarbonate are often used to assess and correct acidosis associated with diabetic ketoacidosis. The available literature, primarily in patients with mild to moderately severe acidosis, does not support the routine use of sodium bicarbonate. Additionally, arterial sampling for blood gas measurement may not be necessary, nor does it appear to substantially add to the care of these patients. While neither intervention may be needed on a routine basis, there are special circumstances when either, or both, of these modalities is indicated and useful.