Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia

Table 1 Helicobacter pylori infection by sex and age in Indonesian people n (%)

Indonesia	H. pylori (+)n= 33	H. pylori (-)n= 261
Sex
Male	9 (8.4)	98 (91.6)
Female	24 (12.8)	163 (87.2)
Age, yr
≤ 30	12 (9.6)	113 (90.4)
31-40	9 (11.5)	69 (88.5)
41-50	7 (14.6)	41 (85.4)
51-60	3 (9.4)	29 (90.6)
≥ 60	2 (18.2)	9 (81.8)
Mean age, yr	36.3 ± 14.6 (SD)	33.7 ± 14.4 (SD)

H. pylori: Helicobacter pylori.

Table 2 Association between Helicobacter pylori infection and interleukin 1β, interleukin 4, interleukin 8, CD14, tumor necrosis factor-α, tyrosine-protein phosphates non-receptor type 11 single nucleotide polymorphism in Indonesian people n (%)

Polymorphism	H. pylori (+)n= 33	H. pylori (-)n= 261	OR1	95%CI1
IL-1β T-31C
TT	8 (24.2)	59 (22.6)	ref
CC	8 (24.2)	73 (28.0)	0.82	0.29-2.32
TC	17 (51.5)	129 (49.4)	1.05	0.42-2.59
TC/CC	25 (75.8)	202 (77.4)	0.96	0.41-2.26
IL-4 T-33C
TT	15 (45.5)	128 (49.0)	ref
CC	2 (6.1)	19 (7.3)	0.83	0.17-3.99
TC	16 (48.5)	114 (43.7)	1.24	0.58-2.64
CC/TC	18 (54.5)	133 (51.0)	1.18	0.56-2.45
IL-8 T-251A
TT	14 (42.4)	98 (37.6)	ref
AA	8 (24.2)	49 (18.8)	1.25	0.48-3.27
TA	11 (33.3)	114 (43.7)	0.74	0.32-1.72
TA/AA	19 (57.6)	163 (62.5)	0.89	0.42-1.88
CD14 C-159T
CC	7 (21.2)	65 (24.9)	ref
TT	8 (24.2)	65 (24.9)	1.09	0.37-3.20
CT	18 (54.6)	131 (50.2)	1.26	0.50-3.19
CT/TT	26 (78.8)	196 (75.1)	1.2	0.50-2.92
TNF-α T-1031C
TT	11 (33.3)	120 (46.0)	ref
CC	6 (18.2)	36 (13.8)	1.99	0.67-5.89
TC	16 (48.5)	105 (40.2)	1.66	0.73-3.76
CC/TC	22 (66.7)	141 (54.0)	1.74	0.80-3.76
PTPN11 G/A at intron 3
GG	17 (51.5)	151 (57.9)	ref
AA	1 (3.0)	17 (6.5)	0.6	0.07-4.86
GA	15 (45.5)	93 (35.6)	1.49	0.70-3.15
GA/AA	16 (48.5)	110 (42.2)	1.37	0.65-2.85

¹Odds rate with CI adjusted for age and sex by logistic regression model. H. pylori: Helicobacter pylori; IL: Interleukin; PTPN11: Tyrosine-protein phosphates non-receptor type 11.

Table 3 Association between Helicobacter pylori infection and allele of interleukin 1β, interleukin 4, interleukin 8, CD14, tumor necrosis factor-α, tyrosine-protein phosphates non-receptor type 11 in Indonesian people n (%)

Allele	H. pylori (+)n= 66	H. pylori (-)n= 522	OR1	95%CI
IL-1β T-31C
T	33 (50.0)	247 (47.3)	ref
C	33 (50.0)	275 (52.7)	1.10	0.70-1.73
IL-4 T-33C
T	46 (69.7)	370 (70.9)	ref
C	20 (30.3)	152 (29.1)	0.95	0.58-1.56
IL-8 T-251A
T	39 (59.1)	310 (59.4)	ref
A	27 (40.9)	212 (40.6)	0.99	0.62-1.57
CD14 C-159T
C	32 (48.5)	261 (50.0)	ref
T	34 (51.5)	261 (50.0)	0.95	0.60-1.49
TNF-α T-1031C
T	38 (57.6)	345 (66.1)	ref
C	28 (42.4)	177 (33.9)	0.73	0.46-1.15
PTPN11 G/A at intron 3
G	49 (74.2)	395 (75.7)	ref
A	17 (25.8)	127 (24.3)	0.94	0.56-1.57

¹Odds rate with CI adjusted for age and sex by logistic regression model. H. pylori: Helicobacter pylori; IL: Interleukin; PTPN11: Tyrosine-protein phosphates non-receptor type 11.