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World J Gastroenterol. Dec 14, 2013; 19(46): 8671-8677
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8671
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8671
Dietary-suppression of hepatic lipogenic enzyme expression in intact male transgenic mice
Maria Notarnicola, Maria Gabriella Caruso, Valeria Tutino, Laboratory of Nutritional Biochemistry, National Institute for Digestive Diseases, Castellana Grotte, 70013 Bari, Italy
Angela Tafaro, Giusy Bianco, Mario Minoia, Animal Facility, National Institute for Digestive Diseases, Castellana Grotte, 70013 Bari, Italy
Antonio Francavilla, Scientific Direction, National Institute for Digestive Diseases, Castellana Grotte, 70013 Bari, Italy
Author contributions: Notarnicola M and Caruso MG have equally contributed to this work; Francavilla A designed the study; Notarnicola M and Tutino V performed the research; Tafaro A, Bianco G and Minoia M performed animal care; Notarnicola M and Caruso MG analyzed the data and wrote the paper.
Correspondence to: Maria Notarnicola, ScD, Laboratory of Nutritional Biochemistry, National Institute for Digestive Diseases, Via della Resistenza, Castellana Grotte, 70013 Bari, Italy. maria.notarnicola@irccsdebellis.it
Telephone: +39-80-4994342 Fax: +39-80-4994313
Received: March 18, 2013
Revised: April 16, 2013
Accepted: May 7, 2013
Published online: December 14, 2013
Revised: April 16, 2013
Accepted: May 7, 2013
Published online: December 14, 2013
Core Tip
Core tip: The olive oil diet significantly reduces the enzymatic activities, as well as the expression of hepatic cell cycle related genes. The addition of drugs as lovastatin and orlistat to olive oil diet more down-regulated the studied lipogenic enzymes, demonstrating that the inhibition of these enzymes with natural components of diet could have a potential benefit in association with canonical chemical substances to counteract hepatic cell proliferation in mice.