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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Determination of 50% endpoint titer using a simple formula  
Muthannan Andavar Ramakrishnan 
World J Virol 5(2):85-86. Published online May 12, 2016. doi: 10.5501/wjv.v5.i2.85
2
Next-generation sequencing in clinical virology: Discovery of new viruses  
Sibnarayan Datta, Raghvendra Budhauliya, Bidisha Das, Soumya Chatterjee, Vanlalhmuaka, Vijay Veer 
World J Virology 4(3):265-276. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.265
3
Serological diagnosis of Epstein-Barr virus infection: Problems and solutions  
Massimo De Paschale, Pierangelo Clerici 
World J Virol 1(1):31-43. Published online Feb 12, 2012. doi: 10.5501/wjv.v1.i1.31
4
5
Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs  
Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Celso Spada, Sérgio Paulo Bydlowski 
World J Virology 4(2):56-77. Published online May 12, 2015. doi: 10.5501/wjv.v4.i2.56
6
Architecture and biogenesis of plus-strand RNA virus replication factories  
David Paul, Ralf Bartenschlager 
World J Virol 2(2):32-48. Published online May 12, 2013. doi: 10.5501/wjv.v2.i2.32
7
Update on hepatitis B and C virus diagnosis  
Livia Melo Villar, Helena Medina Cruz, Jakeline Ribeiro Barbosa, Cristianne Sousa Bezerra, Moyra Machado Portilho, Letícia de Paula Scalioni 
World J Virology 4(4):323-342. Published online Nov 12, 2015. doi: 10.5501/wjv.v4.i4.323
8
West Nile virus: A re-emerging pathogen revisited  
Miguel A Martín-Acebes, Juan-Carlos Saiz 
World J Virol 1(2):51-70. Published online Apr 12, 2012. doi: 10.5501/wjv.v1.i2.51
9
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus  
Catalina Méndez, Chantelle L Ahlenstiel, Anthony D Kelleher 
World J Virology 4(3):219-244. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.219
10
Genotyping and pathotyping of diversified strains of infectious bronchitis viruses circulating in Egypt  
Ali Zanaty, Abdel-Satar Arafa, Naglaa Hagag, Magdy El-Kady 
World J Virol 5(3):125-134. Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.125
11
Pathogenicity of a currently circulating Chinese variant pseudorabies virus in pigs  
Qing-Yuan Yang, Zhe Sun, Fei-Fei Tan, Ling-Hua Guo, Yu-Zhou Wang, Juan Wang, Zhi-Yan Wang, Li-Lin Wang, Xiang-Dong Li, Yan Xiao, Ke-Gong Tian 
World J Virol 5(1):23-30. Published online Feb 12, 2016. doi: 10.5501/wjv.v5.i1.23
12
13
Emerging and re-emerging viruses: A global challenge illustrated by Chikungunya virus outbreaks  
Christian A Devaux 
World J Virol 1(1):11-22. Published online Feb 12, 2012. doi: 10.5501/wjv.v1.i1.11
14
History of polio vaccination  
Anda Baicus 
World J Virol 1(4):108-114. Published online Aug 12, 2012. doi: 10.5501/wjv.v1.i4.108
15
Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results  
Kian Bichoupan, Neeta Tandon, James F Crismale, Joshua Hartman, David Del Bello, Neal Patel, Sweta Chekuri, Alyson Harty, Michel Ng, Keith M Sigel, Meena B Bansal, Priya Grewal, Charissa Y Chang, Jennifer Leong, Gene Y Im, Lawrence U Liu, Joseph A Odin, Nancy Bach, Scott L Friedman, Thomas D Schiano, Ponni V Perumalswami, Douglas T Dieterich, Andrea D Branch 
World J Virol 6(4):59-72. Published online Nov 12, 2017. doi: 10.5501/wjv.v6.i4.59
16
Nuclear domain 10 of the viral aspect  
Yisel A Rivera-Molina, Francisco Puerta Martínez, Qiyi Tang 
World J Virol 2(3):110-122. Published online Aug 12, 2013. doi: 10.5501/wjv.v2.i3.110
17
Microbiology laboratory and the management of mother-child varicella-zoster virus infection  
Massimo De Paschale, Pierangelo Clerici 
World J Virol 5(3):97-124. Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.97
18
19
Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape  
Santo Landolfo, Marco De Andrea, Valentina Dell’Oste, Francesca Gugliesi 
World J Virol 5(3):87-96. Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.87
20
Value of routine dengue diagnosis in endemic countries  
James Ayukepi Ayukekbong, Olufunmilayo G Oyero, Samuel Ekpesu Nnukwu, Henry Nzike Mesumbe, Cajetang Nkong Fobisong 
World J Virol 6(1):9-16. Published online Feb 12, 2017. doi: 10.5501/wjv.v6.i1.9
21
Additional attention to combination antiretroviral therapy-related lipodystrophy  
Norihiko Kobayashi, Masako Nakahara, Masako Oka, Kumiko Saeki 
World J Virol 6(3):49-52. Published online Aug 12, 2017. doi: 10.5501/wjv.v6.i3.49
22
Thymosin alpha 1: A comprehensive review of the literature  
Asimina Dominari, Donald Hathaway III, Krunal Pandav, Wanessa Matos, Sharmi Biswas, Gowry Reddy, Sindhu Thevuthasan, Muhammad Adnan Khan, Anoopa Mathew, Sarabjot Singh Makkar, Madiha Zaidi, Michael Maher Mourad Fahem, Renato Beas, Valeria Castaneda, Trissa Paul, John Halpern, Diana Baralt 
World J Virol 9(5):67-78. Published online Dec 15, 2020. doi: 10.5501/wjv.v9.i5.67
23
Modelling the prevalence of hepatitis C virus amongst blood donors in Libya: An investigation of providing a preventive strategy  
Mohamed A Daw, Amira Shabash, Abdallah El-Bouzedi, Aghnya A Dau, Moktar Habas, Libyan Study Group of Hepatitis and HIV 
World J Virol 5(1):14-22. Published online Feb 12, 2016. doi: 10.5501/wjv.v5.i1.14
24
Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes  
Eyone Jones, Pavel Mazirka, Margaret A McNurlan, Frank Darras, Marie C Gelato, Giuseppe Caso 
World J Virol 6(3):53-58. Published online Aug 12, 2017. doi: 10.5501/wjv.v6.i3.53
25
Regulation of Wnt/β-catenin signaling by herpesviruses  
Kevin J Zwezdaryk, Joseph A Combs, Cindy A Morris, Deborah E Sullivan 
World J Virol 5(4):144-154. Published online Nov 12, 2016. doi: 10.5501/wjv.v5.i4.144
26
Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission  
Karen S SantaCruz, Gulmohor Roy, James Spigel, Elaine L Bearer 
World J Virol 5(1):31-37. Published online Feb 12, 2016. doi: 10.5501/wjv.v5.i1.31
27
Geographic integration of hepatitis C virus: A global threat  
Mohamed A Daw, Abdallah A El-Bouzedi, Mohamed O Ahmed, Aghnyia A Dau, Mohamed M Agnan, Aisha M Drah 
World J Virol 5(4):170-182. Published online Nov 12, 2016. doi: 10.5501/wjv.v5.i4.170
28
Is transfusion-transmitted dengue fever a potential public health threat?  
Bruno Pozzetto, Meriam Memmi, Olivier Garraud 
World J Virology 4(2):113-123. Published online May 12, 2015. doi: 10.5501/wjv.v4.i2.113
29
30
Structural and nucleic acid binding properties of hepatitis delta virus small antigen  
Carolina Alves, Hong Cheng, João Paulo Tavanez, Ana Casaca, Severin Gudima, Heinrich Roder, Celso Cunha 
World J Virol 6(2):26-35. Published online May 12, 2017. doi: 10.5501/wjv.v6.i2.26
31
Current molecular methods for the detection of hepatitis C virus in high risk group population: A systematic review  
Rushna Firdaus, Kallol Saha, Aritra Biswas, Provash Chandra Sadhukhan 
World J Virology 4(1):25-32. Published online Feb 12, 2015. doi: 10.5501/wjv.v4.i1.25
32
Hepatitis delta virus: A fascinating and neglected pathogen  
Celso Cunha, João Paulo Tavanez, Severin Gudima 
World J Virology 4(4):313-322. Published online Nov 12, 2015. doi: 10.5501/wjv.v4.i4.313
33
Immunological-based assays for specific detection of shrimp viruses  
Parin Chaivisuthangkura, Siwaporn Longyant, Paisarn Sithigorngul 
World J Virol 3(1):1-10. Published online Feb 12, 2014. doi: 10.5501/wjv.v3.i1.1
34
Therapeutic and prevention strategies against human enterovirus 71 infection  
Chee Choy Kok 
World J Virology 4(2):78-95. Published online May 12, 2015. doi: 10.5501/wjv.v4.i2.78
35
Active tracking of rejected dried blood samples in a large program in Nigeria  
Auchi Inalegwu, Sunny Phillips, Rawlings Datir, Christopher Chime, Petronilla Ozumba, Samuel Peters, Obinna Ogbanufe, Charles Mensah, Alash’Le Abimiku, Patrick Dakum, Nicaise Ndembi 
World J Virol 5(2):73-81. Published online May 12, 2016. doi: 10.5501/wjv.v5.i2.73
36
Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants  
Sibnarayan Datta, Runu Chakravarty 
World J Virol 5(4):161-169. Published online Nov 12, 2016. doi: 10.5501/wjv.v5.i4.161
37
Rapid genotyping of human rotavirus using SYBR green real-time reverse transcription-polymerase chain reaction with melting curve analysis  
Yupin Tong, Bonita E Lee, Xiaoli L Pang 
World J Virology 4(4):365-371. Published online Nov 12, 2015. doi: 10.5501/wjv.v4.i4.365
38
Molecular interactions between hepatitis B virus and delta virus  
Elham Shirvani-Dastgerdi, Frank Tacke 
World J Virology 4(2):36-41. Published online May 12, 2015. doi: 10.5501/wjv.v4.i2.36
39
Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients  
Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón, Víctor Asensi 
World J Virol 6(2):36-45. Published online May 12, 2017. doi: 10.5501/wjv.v6.i2.36
40
Perinatally infected adolescents living with human immunodeficiency virus (perinatally human immunodeficiency virus)  
Maria Leticia S Cruz, Claudete A Cardoso 
World J Virology 4(3):277-284. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.277
41
Debunking the myths perpetuating low implementation of isoniazid preventive therapy amongst human immunodeficiency virus-infected persons  
Christopher Akolo, Florence Bada, Evaezi Okpokoro, Ogochukwu Nwanne, Sharon Iziduh, Eno Usoroh, Taofeekat Ali, Vivian Ibeziako, Olanrewaju Oladimeji, Michael Odo 
World J Virology 4(2):105-112. Published online May 12, 2015. doi: 10.5501/wjv.v4.i2.105
42
Novel antigen delivery systems  
Maria Trovato, Piergiuseppe De Berardinis 
World J Virology 4(3):156-168. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.156
43
Prevalence of adenovirus and rotavirus infection in immunocompromised patients with acute gastroenteritis in Portugal  
Joana Ribeiro, Delfim Ferreira, Célia Arrabalde, Sandra Almeida, Inês Baldaque, Hugo Sousa 
World J Virology 4(4):372-376. Published online Nov 12, 2015. doi: 10.5501/wjv.v4.i4.372
44
What psychiatric screening and monitoring might be needed with the new generation of hepatitis C treatments?  
Paul J Rowan 
World J Virology 4(1):13-16. Published online Feb 12, 2015. doi: 10.5501/wjv.v4.i1.13
45
Antiretroviral naive and treated patients: Discrepancies of B cell subsets during the natural course of human immunodeficiency virus type 1 infection  
Olga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Apostolia Margariti, Adamantini Georgiou, Dimitrios Bougiouklis, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis, Symeon Metallidis 
World J Virol 5(4):155-160. Published online Nov 12, 2016. doi: 10.5501/wjv.v5.i4.155
46
Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future  
Nathan W Cummins, Andrew D Badley, Mary J Kasten, Rahul Sampath, Zelalem Temesgen, Jennifer A Whitaker, John W Wilson, Joseph D Yao, John Zeuli, Stacey A Rizza 
World J Virol 5(2):63-67. Published online May 12, 2016. doi: 10.5501/wjv.v5.i2.63
47
Paramyxovirus evasion of innate immunity: Diverse strategies for common targets  
Michelle D Audsley, Gregory W Moseley 
World J Virol 2(2):57-70. Published online May 12, 2013. doi: 10.5501/wjv.v2.i2.57
48
Retinoic acid receptor beta promoter methylation and risk of cervical cancer  
Chaninya Wongwarangkana, Nasamon Wanlapakorn, Jira Chansaenroj, Yong Poovorawan 
World J Virol 7(1):1-9. Published online Feb 12, 2018. doi: 10.5501/wjv.v7.i1.1
49
Diagnostic assays developed for the control of foot-and-mouth disease in India  
Gaurav Kumar Sharma, Sonalika Mahajan, Rakesh Matura, Saravanan Subramaniam, Rajeev Ranjan, Jitendra Biswal, Manoranjan Rout, Jajati Keshari Mohapatra, Bana Bihari Dash, Aniket Sanyal, Bramhadev Pattnaik 
World J Virology 4(3):295-302. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.295
50
Middle-East respiratory syndrome coronavirus: Is it worth a world panic?  
Ahmed S Abdel-Moneim 
World J Virology 4(3):185-187. Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.185