Published online Aug 12, 2017. doi: 10.5501/wjv.v6.i3.49
Peer-review started: March 24, 2017
First decision: May 19, 2017
Revised: July 21, 2017
Accepted: August 3, 2017
Article in press: August 5, 2017
Published online: August 12, 2017
Core tip: Development of lipodystrophy in patients receiving combination antiretroviral therapy (cART) has been a serious problem. Although it was first reported in patients taking proteinase inhibitors, other types of anti-human immunodeficiency virus (HIV) agents also cause lipodystrophy. A recent publication in World Journal of Virology reported unexpected synergism among anti-HIV drugs with different mechanisms of action in inhibiting adipogenesis in vitro. To elucidate the molecular basis for cART-related lipodystrophy, multi-faceted approaches should be taken with a deeper understanding of the development and organization of adipose tissues.