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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication  
Ilaria Peluso, Francesco Pallone, Giovanni Monteleone 
World J Gastroenterol 12(35):5606-5610. Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5606
2
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma  
Jun-Jie Xiong, Kiran Altaf, Muhammad A Javed, Wei Huang, Rajarshi Mukherjee, Gang Mai, Robert Sutton, Xu-Bao Liu, Wei-Ming Hu 
World J Gastroenterol 18(45):6657-6668. Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6657
3
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism  
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
4
Role of the endothelium in inflammatory bowel diseases  
Walter E Cromer, J Michael Mathis, Daniel N Granger, Ganta V Chaitanya, J Steven Alexander 
World J Gastroenterol 17(5):578-593. Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.578
5
Gastrointestinal radiation injury: Symptoms, risk factors and mechanisms  
Abobakr K Shadad, Frank J Sullivan, Joseph D Martin, Laurence J Egan 
World J Gastroenterol 19(2):185-198. Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.185
6
New trends in molecular and cellular biomarker discovery for colorectal cancer  
Parisa Aghagolzadeh, Ramin Radpour 
World J Gastroenterol 22(25):5678-5693. Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
7
8
9
Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review  
Kuan-Yin Lin, Guan-Jhou Chen, Yu-Lin Lee, Yi-Chia Huang, Aristine Cheng, Hsin-Yun Sun, Sui-Yuan Chang, Chun-Eng Liu, Chien-Ching Hung 
World J Gastroenterol 23(20):3589-3606. Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
10
Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound  
Feng-Hua Li, Jing Hao, Jian-Guo Xia, Hong-Li Li, Hua Fang 
World J Gastroenterol 11(29):4560-4565. Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4560
11
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response  
Behzad Yeganeh, Adel Rezaei Moghadam, Javad Alizadeh, Emilia Wiechec, Seyed Moayed Alavian, Mohammad Hashemi, Bita Geramizadeh, Afshin Samali, Kamran Bagheri Lankarani, Martin Post, Payam Peymani, Kevin M Coombs, Saeid Ghavami 
World J Gastroenterol 21(47):13225-13239. Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13225
12
Hepatitis B virus therapy: What’s the future holding for us?  
Sobia Manzoor, Muhammad Saalim, Muhammad Imran, Saleha Resham, Javed Ashraf 
World J Gastroenterol 21(44):12558-12575. Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12558
13
Hemorrhoids: From basic pathophysiology to clinical management  
Varut Lohsiriwat 
World J Gastroenterol 18(17):2009-2017. Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2009
14
Role of the normal gut microbiota  
Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, D Nageshwar Reddy 
World J Gastroenterol 21(29):8787-8803. Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8787
15
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer  
Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi 
World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117
16
Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment  
Traci L Testerman, James Morris 
World J Gastroenterol 20(36):12781-12808. Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12781
17
Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review  
Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Adele Fornelli, Michele Masetti, Andrea Tura, Fabio Grizzi, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Giorgia Acquaviva, Luca di Tommaso, Arrigo Bondi, Michela Visani, Sergio Sabbatani, Laura Pontoriero, Carlo Fabbri, Andrea Cuppini, Annalisa Pession, Elio Jovine 
World J Gastroenterol 21(45):12896-12953. Published online Dec 7, 2015. doi: 10.3748/wjg.v21.i45.12896
18
Laparoscopic approach in gastrointestinal emergencies  
Rosa M Jimenez Rodriguez, Juan José Segura-Sampedro, Mercedes Flores-Cortés, Francisco López-Bernal, Cristobalina Martín, Verónica Pino Diaz, Felipe Pareja Ciuro, Javier Padillo Ruiz 
World J Gastroenterol 22(9):2701-2710. Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2701
19
High antibiotic resistance rate: A difficult issue for Helicobacter pylori eradication treatment  
Mei Zhang 
World J Gastroenterol 21(48):13432-13437. Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13432
20
Celiac disease: Prevalence, diagnosis, pathogenesis and treatment  
Naiyana Gujral, Hugh J Freeman, Alan BR Thomson 
World J Gastroenterol 18(42):6036-6059. Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
21
Pancreatic fluid collections: What is the ideal imaging technique?  
Narendra Dhaka, Jayanta Samanta, Suman Kochhar, Navin Kalra, Sreekanth Appasani, Manish Manrai, Rakesh Kochhar 
World J Gastroenterol 21(48):13403-13410. Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13403
22
Reversibility and heritability of liver fibrosis: Implications for research and therapy  
Hussein M Atta 
World J Gastroenterol 21(17):5138-5148. Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5138
23
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients  
Lynne V McFarland 
World J Gastroenterol 16(18):2202-2222. Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2202
24
Exploring alternative treatments for Helicobacter pylori infection  
Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-Herrera, Irma Romero 
World J Gastroenterol 20(6):1450-1469. Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
25
Recent advances in the molecular diagnostics of gastric cancer  
Mitsuro Kanda, Yasuhiro Kodera 
World J Gastroenterol 21(34):9838-9852. Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
26
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!  
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu 
World J Gastroenterol 23(21):3771-3783. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3771
27
Small intestinal vascular malformation bleeding: A case report with imaging findings  
Jun Cui, Liu-Ye Huang, Shu-Juan Lin, Long-Zhi Yi, Cheng-Rong Wu, Bo Zhang 
World J Gastroenterol 20(38):14076-14078. Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.14076
28
Diet therapy for inflammatory bowel diseases: The established and the new  
Franziska Durchschein, Wolfgang Petritsch, Heinz F Hammer 
World J Gastroenterol 22(7):2179-2194. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2179
29
Anemia and iron deficiency in gastrointestinal and liver conditions  
Jürgen Stein, Susan Connor, Garth Virgin, David Eng Hui Ong, Lisandro Pereyra 
World J Gastroenterol 22(35):7908-7925. Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7908
30
Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis  
Yasushi Yoshimatsu, Akihiro Yamada, Ryuichi Furukawa, Koji Sono, Aisaku Osamura, Kentaro Nakamura, Hiroshi Aoki, Yukiko Tsuda, Nobuo Hosoe, Nobuo Takada, Yasuo Suzuki 
World J Gastroenterol 21(19):5985-5994. Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5985
31
Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence  
Jie Tao, Xin-Sen Xu, Yan-Zhou Song, Kai Qu, Qi-Fei Wu, Rui-Tao Wang, Fan-Di Meng, Ji-Chao Wei, Shun-Bin Dong, Yue-Lang Zhang, Min-Hui Tai, Ya-Feng Dong, Lin Wang, Chang Liu 
World J Gastroenterol 20(28):9497-9505. Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9497
32
Liver resection and metabolic disorders: An undescribed mechanism leading to postoperative mortality  
Alban Zarzavadjian Le Bian, Renato Costi, Mohamed Said Sbai-Idrissi, Claude Smadja 
World J Gastroenterol 20(39):14455-14462. Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14455
33
Alimentary tract duplications in newborns and children: Diagnostic aspects and the role of laparoscopic treatment  
Jan Patiño Mayer, Marcos Bettolli 
World J Gastroenterol 20(39):14263-14271. Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14263
34
Diet and microbiota in inflammatory bowel disease: The gut in disharmony  
Davy C M Rapozo, Claudio Bernardazzi, Heitor Siffert Pereira de Souza 
World J Gastroenterol 23(12):2124-2140. Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2124
35
Nuclear receptors and pathogenesis of pancreatic cancer  
Simone Polvani, Mirko Tarocchi, Sara Tempesti, Andrea Galli 
World J Gastroenterol 20(34):12062-12081. Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12062
36
Gut microbiota imbalance and colorectal cancer  
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
37
Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease  
Vikas Gupta, Xian-Jun Mah, Maria Carmela Garcia, Christina Antonypillai, David van der Poorten 
World J Gastroenterol 21(37):10621-10635. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10621
38
Brain-gut-microbiota axis in Parkinson's disease  
Agata Mulak, Bruno Bonaz 
World J Gastroenterol 21(37):10609-10620. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10609
39
Nonalcoholic fatty liver disease: Evolving paradigms  
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi, Luigi Elio Adinolfi 
World J Gastroenterol 23(36):6571-6592. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6571
40
Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy  
Renato Costi, Alessandro Gnocchi, Francesco Di Mario, Leopoldo Sarli 
World J Gastroenterol 20(37):13382-13401. Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13382
41
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?  
Paul J Kennedy, John F Cryan, Timothy G Dinan, Gerard Clarke 
World J Gastroenterol 20(39):14105-14125. Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14105
42
Diet and nutritional factors in inflammatory bowel diseases  
Danuta Owczarek, Tomasz Rodacki, Renata Domagała-Rodacka, Dorota Cibor, Tomasz Mach 
World J Gastroenterol 22(3):895-905. Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.895
43
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies  
Eleonora Distrutti, Lorenzo Monaldi, Patrizia Ricci, Stefano Fiorucci 
World J Gastroenterol 22(7):2219-2241. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2219
44
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review  
Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda 
World J Gastroenterol 23(36):6549-6570. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6549
45
Autoimmune gastritis: Pathologist’s viewpoint  
Irene Coati, Matteo Fassan, Fabio Farinati, David Y Graham, Robert M Genta, Massimo Rugge 
World J Gastroenterol 21(42):12179-12189. Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12179
46
Gastric cancer: Current status of lymph node dissection  
Maurizio Degiuli, Giovanni De Manzoni, Alberto Di Leo, Domenico D’Ugo, Erica Galasso, Daniele Marrelli, Roberto Petrioli, Karol Polom, Franco Roviello, Francesco Santullo, Mario Morino 
World J Gastroenterol 22(10):2875-2893. Published online Mar 14, 2016. doi: 10.3748/wjg.v22.i10.2875
47
Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma  
Gang Wang, Jia-Hui Chen, Yong Qiang, Dong-Zhi Wang, Zhong Chen 
World J Gastroenterol 21(13):3983-3993. Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3983
48
Technical skills and training of upper gastrointestinal endoscopy for new beginners  
Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee 
World J Gastroenterol 21(3):759-785. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.759
49
Gastroenteric tube feeding: Techniques, problems and solutions  
Irina Blumenstein, Yogesh M Shastri, Jürgen Stein 
World J Gastroenterol 20(26):8505-8524. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8505
50
Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells  
Michael Friberg Bruun Nielsen, Michael Bau Mortensen, Sönke Detlefsen 
World J Gastroenterol 22(9):2678-2700. Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2678