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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review  
Kuan-Yin Lin, Guan-Jhou Chen, Yu-Lin Lee, Yi-Chia Huang, Aristine Cheng, Hsin-Yun Sun, Sui-Yuan Chang, Chun-Eng Liu, Chien-Ching Hung 
World J Gastroenterol 23(20):3589-3606. Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
2
Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication  
Ilaria Peluso, Francesco Pallone, Giovanni Monteleone 
World J Gastroenterol 12(35):5606-5610. Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5606
3
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism  
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
4
Hemorrhoids: From basic pathophysiology to clinical management  
Varut Lohsiriwat 
World J Gastroenterol 18(17):2009-2017. Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2009
5
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma  
Jun-Jie Xiong, Kiran Altaf, Muhammad A Javed, Wei Huang, Rajarshi Mukherjee, Gang Mai, Robert Sutton, Xu-Bao Liu, Wei-Ming Hu 
World J Gastroenterol 18(45):6657-6668. Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6657
6
Role of the endothelium in inflammatory bowel diseases  
Walter E Cromer, J Michael Mathis, Daniel N Granger, Ganta V Chaitanya, J Steven Alexander 
World J Gastroenterol 17(5):578-593. Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.578
7
Role of the normal gut microbiota  
Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, D Nageshwar Reddy 
World J Gastroenterol 21(29):8787-8803. Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8787
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10
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C  
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska, Danuta Januszkiewicz-Lewandowska 
World J Gastroenterol 23(21):3815-3824. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815
11
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes  
Andrew McGuigan, Paul Kelly, Richard C Turkington, Claire Jones, Helen G Coleman, R Stephen McCain 
World J Gastroenterol 24(43):4846-4861. Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4846
12
Gastrointestinal radiation injury: Symptoms, risk factors and mechanisms  
Abobakr K Shadad, Frank J Sullivan, Joseph D Martin, Laurence J Egan 
World J Gastroenterol 19(2):185-198. Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.185
13
New trends in molecular and cellular biomarker discovery for colorectal cancer  
Parisa Aghagolzadeh, Ramin Radpour 
World J Gastroenterol 22(25):5678-5693. Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
14
Technical skills and training of upper gastrointestinal endoscopy for new beginners  
Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee 
World J Gastroenterol 21(3):759-785. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.759
15
Anemia and iron deficiency in gastrointestinal and liver conditions  
Jürgen Stein, Susan Connor, Garth Virgin, David Eng Hui Ong, Lisandro Pereyra 
World J Gastroenterol 22(35):7908-7925. Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7908
16
Nonalcoholic fatty liver disease: Evolving paradigms  
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi, Luigi Elio Adinolfi 
World J Gastroenterol 23(36):6571-6592. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6571
17
Celiac disease: Prevalence, diagnosis, pathogenesis and treatment  
Naiyana Gujral, Hugh J Freeman, Alan BR Thomson 
World J Gastroenterol 18(42):6036-6059. Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
18
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!  
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu 
World J Gastroenterol 23(21):3771-3783. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3771
19
Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment  
Traci L Testerman, James Morris 
World J Gastroenterol 20(36):12781-12808. Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12781
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22
Exploring alternative treatments for Helicobacter pylori infection  
Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-Herrera, Irma Romero 
World J Gastroenterol 20(6):1450-1469. Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
23
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer  
Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi 
World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117
24
Gut microbiota in autism and mood disorders  
Francesca Mangiola, Gianluca Ianiro, Francesco Franceschi, Stefano Fagiuoli, Giovanni Gasbarrini, Antonio Gasbarrini 
World J Gastroenterol 22(1):361-368. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.361
25
Hepatitis B virus therapy: What’s the future holding for us?  
Sobia Manzoor, Muhammad Saalim, Muhammad Imran, Saleha Resham, Javed Ashraf 
World J Gastroenterol 21(44):12558-12575. Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12558
26
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review  
Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda 
World J Gastroenterol 23(36):6549-6570. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6549
27
Brain-gut-microbiota axis in Parkinson's disease  
Agata Mulak, Bruno Bonaz 
World J Gastroenterol 21(37):10609-10620. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10609
28
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response  
Behzad Yeganeh, Adel Rezaei Moghadam, Javad Alizadeh, Emilia Wiechec, Seyed Moayed Alavian, Mohammad Hashemi, Bita Geramizadeh, Afshin Samali, Kamran Bagheri Lankarani, Martin Post, Payam Peymani, Kevin M Coombs, Saeid Ghavami 
World J Gastroenterol 21(47):13225-13239. Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13225
29
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients  
Lynne V McFarland 
World J Gastroenterol 16(18):2202-2222. Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2202
30
Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound  
Feng-Hua Li, Jing Hao, Jian-Guo Xia, Hong-Li Li, Hua Fang 
World J Gastroenterol 11(29):4560-4565. Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4560
31
Gut microbiota imbalance and colorectal cancer  
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
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Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model  
Jun Qian, Elsie Oppermann, Andreas Tran, Ulli Imlau, Kun Qian, Thomas Josef Vogl 
World J Gastroenterol 22(21):5042-5049. Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5042
34
Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer  
Karoliina Paarnio, Sara Väyrynen, Kai Klintrup, Pasi Ohtonen, Markus J Mäkinen, Jyrki Mäkelä, Tuomo J Karttunen 
World J Gastroenterol 23(26):4831-4838. Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4831
35
Diet and nutritional factors in inflammatory bowel diseases  
Danuta Owczarek, Tomasz Rodacki, Renata Domagała-Rodacka, Dorota Cibor, Tomasz Mach 
World J Gastroenterol 22(3):895-905. Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.895
36
Diet therapy for inflammatory bowel diseases: The established and the new  
Franziska Durchschein, Wolfgang Petritsch, Heinz F Hammer 
World J Gastroenterol 22(7):2179-2194. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2179
37
Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease  
Vikas Gupta, Xian-Jun Mah, Maria Carmela Garcia, Christina Antonypillai, David van der Poorten 
World J Gastroenterol 21(37):10621-10635. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10621
38
Diabetes and gastric cancer: The potential links  
Chin-Hsiao Tseng, Farn-Hsuan Tseng 
World J Gastroenterol 20(7):1701-1711. Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1701
39
Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine  
Lekha Saha 
World J Gastroenterol 20(22):6759-6773. Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6759
40
Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review  
Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Adele Fornelli, Michele Masetti, Andrea Tura, Fabio Grizzi, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Giorgia Acquaviva, Luca di Tommaso, Arrigo Bondi, Michela Visani, Sergio Sabbatani, Laura Pontoriero, Carlo Fabbri, Andrea Cuppini, Annalisa Pession, Elio Jovine 
World J Gastroenterol 21(45):12896-12953. Published online Dec 7, 2015. doi: 10.3748/wjg.v21.i45.12896
41
New obesity classification criteria as a tool for bariatric surgery indication  
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo 
World J Gastroenterol 22(2):681-703. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.681
42
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase  
Zhen Li, Qian Ding, Li-Ping Ling, Ying Wu, Dong-Xiao Meng, Xiao Li, Chun-Qing Zhang 
World J Gastroenterol 24(7):819-832. Published online Feb 21, 2018. doi: 10.3748/wjg.v24.i7.819
43
Gastroenteric tube feeding: Techniques, problems and solutions  
Irina Blumenstein, Yogesh M Shastri, Jürgen Stein 
World J Gastroenterol 20(26):8505-8524. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8505
44
Differentiating Crohn’s disease from intestinal tuberculosis  
Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja 
World J Gastroenterol 25(4):418-432. Published online Jan 28, 2019. doi: 10.3748/wjg.v25.i4.418
45
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies  
Eleonora Distrutti, Lorenzo Monaldi, Patrizia Ricci, Stefano Fiorucci 
World J Gastroenterol 22(7):2219-2241. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2219
46
Influence of gut microbiota on neuropsychiatric disorders  
María Carmen Cenit, Yolanda Sanz, Pilar Codoñer-Franch 
World J Gastroenterol 23(30):5486-5498. Published online Aug 14, 2017. doi: 10.3748/wjg.v23.i30.5486
47
Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy  
Renato Costi, Alessandro Gnocchi, Francesco Di Mario, Leopoldo Sarli 
World J Gastroenterol 20(37):13382-13401. Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13382
48
Laparoscopic approach in gastrointestinal emergencies  
Rosa M Jimenez Rodriguez, Juan José Segura-Sampedro, Mercedes Flores-Cortés, Francisco López-Bernal, Cristobalina Martín, Verónica Pino Diaz, Felipe Pareja Ciuro, Javier Padillo Ruiz 
World J Gastroenterol 22(9):2701-2710. Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2701
49
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects  
Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela, Andrew FG Quest 
World J Gastroenterol 24(28):3071-3089. Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3071
50
Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis  
Osamu Toyoshima, Toshihiro Nishizawa, Kazuhiko Koike 
World J Gastroenterol 26(5):466-477. Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.466