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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication  
Ilaria Peluso, Francesco Pallone, Giovanni Monteleone 
World J Gastroenterol 12(35):5606-5610. Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5606
2
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism  
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
3
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma  
Jun-Jie Xiong, Kiran Altaf, Muhammad A Javed, Wei Huang, Rajarshi Mukherjee, Gang Mai, Robert Sutton, Xu-Bao Liu, Wei-Ming Hu 
World J Gastroenterol 18(45):6657-6668. Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6657
4
Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review  
Kuan-Yin Lin, Guan-Jhou Chen, Yu-Lin Lee, Yi-Chia Huang, Aristine Cheng, Hsin-Yun Sun, Sui-Yuan Chang, Chun-Eng Liu, Chien-Ching Hung 
World J Gastroenterol 23(20):3589-3606. Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
5
Role of the endothelium in inflammatory bowel diseases  
Walter E Cromer, J Michael Mathis, Daniel N Granger, Ganta V Chaitanya, J Steven Alexander 
World J Gastroenterol 17(5):578-593. Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.578
6
Hemorrhoids: From basic pathophysiology to clinical management  
Varut Lohsiriwat 
World J Gastroenterol 18(17):2009-2017. Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2009
7
8
Gastrointestinal radiation injury: Symptoms, risk factors and mechanisms  
Abobakr K Shadad, Frank J Sullivan, Joseph D Martin, Laurence J Egan 
World J Gastroenterol 19(2):185-198. Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.185
9
Role of the normal gut microbiota  
Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, D Nageshwar Reddy 
World J Gastroenterol 21(29):8787-8803. Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8787
10
New trends in molecular and cellular biomarker discovery for colorectal cancer  
Parisa Aghagolzadeh, Ramin Radpour 
World J Gastroenterol 22(25):5678-5693. Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
11
12
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C  
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska, Danuta Januszkiewicz-Lewandowska 
World J Gastroenterol 23(21):3815-3824. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815
13
Celiac disease: Prevalence, diagnosis, pathogenesis and treatment  
Naiyana Gujral, Hugh J Freeman, Alan BR Thomson 
World J Gastroenterol 18(42):6036-6059. Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
14
Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment  
Traci L Testerman, James Morris 
World J Gastroenterol 20(36):12781-12808. Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12781
15
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes  
Andrew McGuigan, Paul Kelly, Richard C Turkington, Claire Jones, Helen G Coleman, R Stephen McCain 
World J Gastroenterol 24(43):4846-4861. Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4846
16
Hepatitis B virus therapy: What’s the future holding for us?  
Sobia Manzoor, Muhammad Saalim, Muhammad Imran, Saleha Resham, Javed Ashraf 
World J Gastroenterol 21(44):12558-12575. Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12558
17
Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound  
Feng-Hua Li, Jing Hao, Jian-Guo Xia, Hong-Li Li, Hua Fang 
World J Gastroenterol 11(29):4560-4565. Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4560
18
Nonalcoholic fatty liver disease: Evolving paradigms  
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi, Luigi Elio Adinolfi 
World J Gastroenterol 23(36):6571-6592. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6571
19
Anemia and iron deficiency in gastrointestinal and liver conditions  
Jürgen Stein, Susan Connor, Garth Virgin, David Eng Hui Ong, Lisandro Pereyra 
World J Gastroenterol 22(35):7908-7925. Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7908
20
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response  
Behzad Yeganeh, Adel Rezaei Moghadam, Javad Alizadeh, Emilia Wiechec, Seyed Moayed Alavian, Mohammad Hashemi, Bita Geramizadeh, Afshin Samali, Kamran Bagheri Lankarani, Martin Post, Payam Peymani, Kevin M Coombs, Saeid Ghavami 
World J Gastroenterol 21(47):13225-13239. Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13225
21
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer  
Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi 
World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117
22
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!  
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu 
World J Gastroenterol 23(21):3771-3783. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3771
23
Exploring alternative treatments for Helicobacter pylori infection  
Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-Herrera, Irma Romero 
World J Gastroenterol 20(6):1450-1469. Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
24
25
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients  
Lynne V McFarland 
World J Gastroenterol 16(18):2202-2222. Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2202
26
Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review  
Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Adele Fornelli, Michele Masetti, Andrea Tura, Fabio Grizzi, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Giorgia Acquaviva, Luca di Tommaso, Arrigo Bondi, Michela Visani, Sergio Sabbatani, Laura Pontoriero, Carlo Fabbri, Andrea Cuppini, Annalisa Pession, Elio Jovine 
World J Gastroenterol 21(45):12896-12953. Published online Dec 7, 2015. doi: 10.3748/wjg.v21.i45.12896
27
Technical skills and training of upper gastrointestinal endoscopy for new beginners  
Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee 
World J Gastroenterol 21(3):759-785. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.759
28
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review  
Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda 
World J Gastroenterol 23(36):6549-6570. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6549
29
Diet therapy for inflammatory bowel diseases: The established and the new  
Franziska Durchschein, Wolfgang Petritsch, Heinz F Hammer 
World J Gastroenterol 22(7):2179-2194. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2179
30
Laparoscopic approach in gastrointestinal emergencies  
Rosa M Jimenez Rodriguez, Juan José Segura-Sampedro, Mercedes Flores-Cortés, Francisco López-Bernal, Cristobalina Martín, Verónica Pino Diaz, Felipe Pareja Ciuro, Javier Padillo Ruiz 
World J Gastroenterol 22(9):2701-2710. Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2701
31
Brain-gut-microbiota axis in Parkinson's disease  
Agata Mulak, Bruno Bonaz 
World J Gastroenterol 21(37):10609-10620. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10609
32
Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease  
Vikas Gupta, Xian-Jun Mah, Maria Carmela Garcia, Christina Antonypillai, David van der Poorten 
World J Gastroenterol 21(37):10621-10635. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10621
33
Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer  
Karoliina Paarnio, Sara Väyrynen, Kai Klintrup, Pasi Ohtonen, Markus J Mäkinen, Jyrki Mäkelä, Tuomo J Karttunen 
World J Gastroenterol 23(26):4831-4838. Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4831
34
35
Gut microbiota imbalance and colorectal cancer  
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
36
Gut microbiota in autism and mood disorders  
Francesca Mangiola, Gianluca Ianiro, Francesco Franceschi, Stefano Fagiuoli, Giovanni Gasbarrini, Antonio Gasbarrini 
World J Gastroenterol 22(1):361-368. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.361
37
High antibiotic resistance rate: A difficult issue for Helicobacter pylori eradication treatment  
Mei Zhang 
World J Gastroenterol 21(48):13432-13437. Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13432
38
Pancreatic fluid collections: What is the ideal imaging technique?  
Narendra Dhaka, Jayanta Samanta, Suman Kochhar, Navin Kalra, Sreekanth Appasani, Manish Manrai, Rakesh Kochhar 
World J Gastroenterol 21(48):13403-13410. Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13403
39
Reversibility and heritability of liver fibrosis: Implications for research and therapy  
Hussein M Atta 
World J Gastroenterol 21(17):5138-5148. Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5138
40
New obesity classification criteria as a tool for bariatric surgery indication  
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo 
World J Gastroenterol 22(2):681-703. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.681
41
Recent advances in the molecular diagnostics of gastric cancer  
Mitsuro Kanda, Yasuhiro Kodera 
World J Gastroenterol 21(34):9838-9852. Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
42
Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy  
Renato Costi, Alessandro Gnocchi, Francesco Di Mario, Leopoldo Sarli 
World J Gastroenterol 20(37):13382-13401. Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13382
43
Diet and microbiota in inflammatory bowel disease: The gut in disharmony  
Davy C M Rapozo, Claudio Bernardazzi, Heitor Siffert Pereira de Souza 
World J Gastroenterol 23(12):2124-2140. Published online Mar 28, 2017. doi: 10.3748/wjg.v23.i12.2124
44
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies  
Eleonora Distrutti, Lorenzo Monaldi, Patrizia Ricci, Stefano Fiorucci 
World J Gastroenterol 22(7):2219-2241. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2219
45
Diet and nutritional factors in inflammatory bowel diseases  
Danuta Owczarek, Tomasz Rodacki, Renata Domagała-Rodacka, Dorota Cibor, Tomasz Mach 
World J Gastroenterol 22(3):895-905. Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.895
46
Differentiating Crohn’s disease from intestinal tuberculosis  
Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja 
World J Gastroenterol 25(4):418-432. Published online Jan 28, 2019. doi: 10.3748/wjg.v25.i4.418
47
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?  
Paul J Kennedy, John F Cryan, Timothy G Dinan, Gerard Clarke 
World J Gastroenterol 20(39):14105-14125. Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14105
48
Gastroenteric tube feeding: Techniques, problems and solutions  
Irina Blumenstein, Yogesh M Shastri, Jürgen Stein 
World J Gastroenterol 20(26):8505-8524. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8505
49
Diabetes and gastric cancer: The potential links  
Chin-Hsiao Tseng, Farn-Hsuan Tseng 
World J Gastroenterol 20(7):1701-1711. Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1701
50
Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis  
Yasushi Yoshimatsu, Akihiro Yamada, Ryuichi Furukawa, Koji Sono, Aisaku Osamura, Kentaro Nakamura, Hiroshi Aoki, Yukiko Tsuda, Nobuo Hosoe, Nobuo Takada, Yasuo Suzuki 
World J Gastroenterol 21(19):5985-5994. Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5985