Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
Revised: December 21, 2013
Accepted: January 3, 2014
Published online: February 14, 2014
Core tip:Helicobacter pylori (H. pylori) plays a role in several gastric diseases. Current anti-H. pylori therapy fails in more than 20% of cases, primarily due to antimicrobial resistance and patient non-adherence. This situation has encouraged the search for other approaches to control H. pylori infection. This review discusses advances in the development of an H. pylori vaccine and new treatments based on plants, probiotics, nutraceuticals, microorganisms, peptides and intragastric violet light irradiation. Alternative therapies have not been effective in eradicating the bacteria in vivo but are promising as complementary treatments diseases associated with H. pylori infection.