Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer
Jonathan Landy, Ailsa L Hart, IBD Unit, St Mark’s Hospital, Harrow, London HA1 3UJ, United Kingdom
Jonathan Landy, Emma Ronde, Nick English, Ailsa L Hart, Stella C Knight, Hafid Omar Al-Hassi, Antigen Presentation Research Group, Department of Immunology, Imperial College, London HA1 3UJ, United Kingdom
Sue K Clark, Department of Biosurgery and Surgical Technology, Imperial College, London HA1 3UJ, United Kingdom
Paul J Ciclitira, Department of Gastroenterology, The Rayne Institute, St Thomas’ Hospital, London HA1 3UJ, United Kingdom
Author contributions: Landy J and Al-Hassi HO contributed equally to the conception of the article, literature search and interpretation, writing the article and making critical revisions related to important intellectual content of the manuscript, and final approval of the version of the article to be published; Ronde E contributed to the literature search, drafting of the article and final approval of the version of the article to be published; English N was responsible for the electron micrographs presented in the figures; Clark SK, Knight SC, Hart AL and Ciclitira PJ made critical revisions related to important intellectual content of the manuscript, and the final approval of the version of the article to be published.
Supported by The Association for International Cancer Research (AICR, to Dr. Al-Hassi HO), Scotland; Funded by the AICR, grant No. 120234; a BBSRC Strategic Research Grant (to English N and Knight SC; WMNIP33458); the St Mark’s Hospital Foundation, United Kingdom.
Conflict-of-interest statement: None of the authors have any conflicts of interest or financial disclosures; and Dr. Hart has spoken for and is on the advisory board for MSD, Shire and Abbott.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Paul J Ciclitira, Professor, Department of Gastroenterology, The Rayne Institute, St Thomas’ Hospital, 4th Floor Lambeth Wing, London SE1 7EH, United Kingdom. firstname.lastname@example.org
Telephone: +44-20-76202597 Fax: +44-20-72610667
Received: June 18, 2015
Peer-review started: June 21, 2015
First decision: August 26, 2015
Revised: September 19, 2015
Accepted: December 19, 2015
Article in press: December 19, 2015
Published online: March 21, 2016