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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2017; 23(30): 5486-5498
Published online Aug 14, 2017. doi: 10.3748/wjg.v23.i30.5486
Published online Aug 14, 2017. doi: 10.3748/wjg.v23.i30.5486
Influence of gut microbiota on neuropsychiatric disorders
María Carmen Cenit, Yolanda Sanz, Microbial Ecology, Nutrition and Health Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Paterna, 46980 Valencia, Spain
Pilar Codoñer-Franch, Department of Pediatrics, Dr. Peset University Hospital, 46017 Valencia, Spain
María Carmen Cenit, Pilar Codoñer-Franch, Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain
Author contributions: Cenit MC wrote the first draft of the manuscript; Sanz Y and Codoñer-Franch P have contributed substantially to the writing and revising of the manuscript; Codoñer-Franch P designed the aim of the editorial; all the authors have made substantial intellectual contributions, take responsibility to the paper and give final approval of the version to be submitted.
Supported by Spanish Ministry of Economy and Competitiveness (MINECO) , No. AGL2014-52101-P ; A Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain) , No. CD14/00237 (Cenit MC) .
Conflict-of-interest statement: All the authors declare no conflict of interest related to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pilar Codoñer-Franch, MD, PhD, Department of Pediatrics, Dr. Peset University Hospital, Avenida Gaspar Aguilar 90, Valencia 46017, Spain. pilar.codoner@uv.es
Telephone: +34-963-864170 Fax: +34-963-864815
Received: February 8, 2017
Peer-review started: February 9, 2017
First decision: April 17, 2017
Revised: May 8, 2017
Accepted: July 4, 2017
Article in press: July 4, 2017
Published online: August 14, 2017
Peer-review started: February 9, 2017
First decision: April 17, 2017
Revised: May 8, 2017
Accepted: July 4, 2017
Article in press: July 4, 2017
Published online: August 14, 2017
Core Tip
Core tip: The gut microbiota has been revealed as an additional regulator of the gut-brain axis, which may be involved in many neurodevelopmental and neurodegenerative disorders. The modulation of this axis is currently being explored, targeting the gut microbiota in endeavors to improve mental health, especially in early and late life. So far, most of our knowledge is based on animal trials, in which interventions with pro and prebiotics have shown promising results regarding efficacy. Nevertheless, we require further understanding of how the microbiota regulates gut-brain communication and function in order to establish the rationale behind microbiota-based interventions.