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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2016; 22(44): 9694-9705
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9694
Epidemiology of pancreatic cancer
Milena Ilic, Irena Ilic
Milena Ilic, Irena Ilic, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Milena Ilic, MD, PhD, Faculty of Medical Sciences, University of Kragujevac, S. Markovica 69, 34000 Kragujevac, Serbia. drmilenailic@yahoo.com
Telephone: +381-34-306800 Fax: +381-34-306800
Received: July 3, 2016
Peer-review started: July 4, 2016
First decision: August 19, 2016
Revised: August 30, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 28, 2016

Abstract

Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11th most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world. A known cause of pancreatic cancer is tobacco smoking. This risk factor is likely to explain some of the international variations and gender differences. The overall five-year survival rate is about 6% (ranges from 2% to 9%), but this vary very small between developed and developing countries. To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as smoking, obesity, genetics, diabetes, diet, inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease.

Key Words: Pancreatic cancer, Epidemiology, Incidence, Mortality, Trend, Risk factors

Core tip: Pancreatic cancer is the one of leading causes of cancer mortality and one of the most lethal malignant neoplasms across the world. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. The estimated 5-year survival rate for pancreatic cancer is about 5%. The causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as cigarette smoking, positive family history and genetics, diabetes mellitus, obesity, dietary factors, alcohol use, physical inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance.



INTRODUCTION

Pancreatic cancer is the one of leading causes of cancer mortality in developed countries and one of the most lethal malignant neoplasms across the world[1-3]. The two main tumor types of pancreatic cancer are adenocarcinoma (that accounts for about 85% of cases), and pancreatic endocrine tumors (which are make up for less than 5% of all cases)[1,4,5].

Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year (accounts for 4.0% of all deaths), ranking as the seventh leading cause of cancer death in both sexes together[1]. About 338000 people had pancreatic cancer in 2012, making it the 11th most common cancer[1,2].The estimated 5-year survival rate for pancreatic cancer is less than 5%[2,4]. The incidence and mortality of pancreatic cancer worldwide correlated with increasing age and was slightly more common in men than in women[1-3]. In the past decades, pancreatic cancer mortality has been increasing in both genders (for example, in the United States, European countries, Japan, China)[1,3,6-8].

The causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as cigarette smoking, positive family history and genetics, diabetes mellitus, obesity, dietary factors, alcohol use, physical inactivity[9-12].

Understanding the epidemiology of pancreatic cancer could be the key to elucidating the etiology of pancreatic cancer and thus the cornerstone of developing a prevention strategy.

INCIDENCE

The incidence of pancreatic cancer varies greatly across regions and populations. Incidence rates for pancreatic cancer in 2012 were highest in Northern America (7.4 per 100000 people) and Western Europe (7.3 per 100000 people), followed by other regions in Europe and Australia/New Zealand (equally about 6.5 per 100000 people) (Figure 1)[1]. The lowest rates (about 1.0 per 100000 people) were observed in Middle Africa and South-Central Asia. Differences in incidence rates were twenty fold between the populations with the highest rate (Czech Republic - 9.7), and the population with the lowest rate (Pakistan - 0.5). More than half of new cases (55.5%) were registered in more developed regions[1]. Slightly less than half (41.0%; 139363 of cases) of all new cases of pancreatic cancer in 2012 were recorded in the countries of Asia.

Figure 1
Figure 1 Pancreatic cancer incidence and mortality in men and women, by regions, GLOBOCAN 2012 estimates.

There are significant geographic variations in the incidence of pancreatic cancer by genders[1,2,6-8]. The incidence rate of pancreatic cancer among men in 2012 was 4.9 per 100000, and among women 3.6 per 100000 (Figure 2)[1]. In men, the risk of developing pancreatic cancer was high in Armenia (11.9) and Czech Republic (11.8), Slovakia and Hungary (equally - 11.5), then in Japan and Lithuania (equally - 10.6) (Figure 2A). In contrast, the risk of contracting pancreatic cancer in men was the lowest in Pakistan (0.5) and Guinea (0.4). The regions with the highest incidence rates of pancreatic cancer in women were Northern America (6.4 per 100000), Western Europe (6.3), and Northern Europe and Australia/New Zealand (5.9 and 5.4, respectively) (Figure 1)[1]. The lowest rates of pancreatic cancer incidence (less than 1.0 per 100000) were in Middle Africa and Polynesia. Women living in Hungary, Denmark, Finland and Armenia have the greatest risk (aproximatelly 7.5 per 100000) of dying from pancreatic cancer, while women in Tanzania, Guinea, Cameroon, Namibia and Pakistan have the lowest disease risk (less than 1.0 per 100000) (Figure 2B).

Figure 2
Figure 2 Pancreatic cancer incidence in men (A) and women (B), GLOBOCAN 2012 estimates. 1Country with the lowest mortality rates; 2Country with the highest mortality rates. GLOBOCAN 2012 estimates[1].

The incidence rates for both sexes increase with age, the highest in older than 70 years[3,4,6]. It is predominantly a disease of the elderly, and almost 90% of all cases are diagnosed after the age of 55 years[6,13].

Although it is not possible to fully explain the differences in the incidence of pancreatic cancer in different parts of the world, most of the international variation in the incidence of pancreatic cancer has been attributed to exposure to known or suspected risk factors related to lifestyle or the environment[9,10,13]. Tobacco smoking is likely to explain these international variations and gender differences[11]. Some findings may be indicating that obesity may have some effect on differences[14]. Additionally, some findings indicate the role of aging and hereditary and genetic factors. The reasons for higher incidence of pancreatic cancer in men are still insufficiently known: women are either less prone to these kinds of malignant tumors, or are less exposed to risk factors from the environment responsible for their occurrence[9,15]. Besides that, international differences probably reflect diagnostic capacity and the change in use of various diagnostic modalities[16]. In 2012, Europe carried one third of the overall incidence, which likely reflected the more accurate diagnosis of pancreatic cancer rather than etiology[17]. It should be noted that some differences in incidence of pancreatic cancer around the world may be attributed to the quality of registries, which coverage, completeness and accuracy varies by country[18].

MORTALITY

International mortality rates for pancreatic cancer vary significantly in different areas. Rates of mortality from pancreatic cancer in 2012 in both genders were highest in Northern America (6.9 per 100000 people) and Western Europe (6.8), followed by other European regions and Australia/New Zealand (approximately - 6.0, respectively) (Figure 1)[1]. The lowest mortality was recorded in the countries in Middle Africa and South-Central Asia (less than 1.0 per 1000000 people). The differences in mortality rates were nearly fifty fold between the populations with the highest and lowest rate (Armenia vs Tanzania: 8.9 vs 0.2). More than one third (111029 deaths) of all deceased from pancreatic cancer are residents of Europe. Slightly less than half (41.5%; 137251 deaths) of all deaths from pancreatic cancer were recorded in 2012 in Asian countries[1]. More than half (55.8%, 184429 deaths) of deceased of pancreatic cancer were registered in more developed regions. At least deaths were registered in Micronesia/Polynesia. The least number of deaths was registered in Micronesia/Polynesia.

Mortality of pancreatic cancer in both genders increases with age, and almost 90% of all deaths are registered after the age of 55 years[1,3]. The highest mortality rates in 2012 in males were recorded in Central and Eastern Europe (Latvia - 11.9, Hungary - 11.5) (Figure 3A)[1]. The mortality from pancreatic cancer was lowest (less than 1.0 per 100000 people) in Belize and Bahrain. The highest mortality rates in 2012 in females were recorded in Hungary (7.5) and Malta (7.2) (Figure 3B)[1]. The mortality from pancreatic cancer was lowest in women in Belize (0.8).

Figure 3
Figure 3 Pancreatic cancer mortality in men (A) and women (B), GLOBOCAN 2012 estimates. 1Country with the lowest mortality rates; 2Country with the highest mortality rates. GLOBOCAN 2012 estimates[1].

Mortality of pancreatic cancer is almost identical with its incidence, because it is one of the most fatal malignant tumors[19,20]. Reasons for the substantial differences in mortality rates of pancreatic cancer were not completely elucidated. Differences in rates of incidence can be apparent and specious. Specious differences may arise as a result of changes in the diagnosis of diseases and causes of death, as a result of a real shift in the incidence and/or fatality. Data on the incidence/mortality published by WHO are not of the same quality in all countries[18]. Although the quality (accuracy and completeness of cause of death registration, primarily) and the coverage of information in most developing countries can be considered limited, the registry often remains the only available source. Symptoms, signs and insufficiently defined conditions as the underlying cause of death are significantly more often mentioned in Serbia, the Russian Federation and Greece than in more developed countries such as the United states of America, United Kingdom, and Finland, which points to the need for a cautious interpretation of the data statistics of mortality in international comparisons[18]. Pancreatic cancer is difficult to diagnose. Malignant pancreatic neoplasm was among the most common cancers detected at autopsy studies[16,21]. It is known that for pancreatic cancer there is no workable modality of screening, early detection and effective treatment, which has the consequence of survival rates varying very little between developed and developing countries[22]. Current available treatment options for pancreatic cancer are limited. Due to the advanced stage at diagnosis, 80%-90% of patients have unresectable tumours and long-term survival after surgical resection is poor[13,19,23].

High smoking prevalence has been widely recognized as the main contributor to the high mortality rates of pancreatic cancer[11,24]. Numerous evidence support that diet (animal fat and meat consumption, etc.) plays a role in the development of pancreatic cancer[25,26]. In addition, the highest rates for pancreatic cancer mortality in eastern European countries suggested that other factors (including prevalence of diabetes, obesity, alcohol use) could influence the mortality of pancreatic cancer[27].

TEMPORAL TRENDS

Trends for pancreatic cancer mortality varied considerably in the world. Figure 4 represent pancreatic cancer mortality trends in 8 selected countries using official data for pancreatic cancer abstracted from the WHO database over the period 1955 to 2012[1]. For men in most developed countries (United States, the United Kingdom, Australia, Japan and Finland), a rise was observed between the early 1955 and the late 1980s, followed by a leveling off since 1990s (Figure 4A). Thus, rates for men in Eastern and Southern Europe (Hungary and Greece) rose continuously over the observed period. For women in the United Kingdom, Finland, Japan, United States and Australia, rates tended to rise up to the early 1990s, and to level off thereafter (Figure 4B). In Eastern and Southern European countries (such as Hungary and Greece), rates rose from the early 1970s to onwards.

Figure 4
Figure 4 Pancreatic cancer mortality trends among men (A) and women (B) in selected countries. GLOBOCAN 2012 estimates[1].

In the United States, whites and blacks experienced opposite trends in pancreatic cancer death rates between 1975 and 2013[28]. In whites, pancreatic cancer death rates decreased by 0.2% per year from 1095 to 1996 and then increased by 0.4% per year through 2013. In contrast, the rates among blacks increased between 1975 and the late 1990s and then decreased thereafter. Also, in last decades a decreasing trend was found in both sexes in the United Kingdom, Sweden, Australia, the Netherlands, Mexico[13]. An increasing trend in both sexes was noticed in France, Japan, Brazil, Republic of Korea, and most countries of Central (Germany, Hungary), Eastern (Russian Federation, Poland, Romania, Serbia), and Southern Europe (Italy, Spain) [13,29-31].

To date, however, temporal trends in pancreatic cancer incidence and mortality have not been well understood. In both sexes, temporal trends in cigarette smoking prevalence were related to temporal trends in pancreatic cancer mortality with a roughly lag of several decades[9,11,24]. Decreased smoking, particularly in men, has been widely recognized as the main contributor to the decreases in mortality trends from pancreatic cancer in developed countries[24,32]. The mortality rate of pancreatic cancer began to decline earlier in the countries where the tobacco control started to be implemented earlier (such as United States, the United Kingdom, Australia). However, the recent increasing trends in some countries in the European Union suggest that other factors (including mainly obesity, physical inactivity, diabetes, and dietary factors), besides smoking, may have influenced the pancreatic cancer mortality[20,22,31,33]. In recent years, people in developing countries adopt lifestyles and behaviors that are typical for developed countries, such as cigarette smoking, higher consumption of saturated fat and calorie-rich foods, and reduced physical activity[25,27,34]. Besides, the trends might be due to disparities in socioeconomic circumstances between high- and low-income areas. Improved diagnostic and death certification of the disease might also partially explain the observed figures, at least part of the recent trends in some countries of Southern, Central and Eastern Europe[18,27,31]. It is unlikely, however, that progress in the treatment of pancreatic cancer could have a significant impact on mortality trends, also given the negligible changes in survival over the last decades[19,22,23,35]. Also, it is known that the changes in coding of pancreatic cancer had minimal influence on mortality trends of pancreatic cancer in the second half of the XX century[18,36].

SURVIVAL

Cancer of the pancreas remains one of the most deadly common cancer types: the Mortality/Incidence ratio is 98%[1]. The overall five-year survival rate is about 6% (ranges from 2% to 9%), but this partly reflects varying data quality worldwide[37,38]. For pancreatic cancer, survival rates vary very small between developed and developing countries[37].

Based on the United States National Cancer Institute’ data for pancreatic cancer in both sexes and all races, 9.4% are diagnosed at the local stage while the 5-year survival for localized disease was 29.3% during 2006-2012[3]. More than half (52%) of all cases were diagnosed at the distant stage with the 5-year survival rates of 2.6%.

Some intercountry survival differences for pancreatic cancers exist over Europe: 5-year survival rate was less than 3% in both sexes in England and Wales[39], Denmark and Sweden - 3.8%[22], in Italy - 1.2%[40]. EUROCARE Working Group analyzed the survival of cancer patients diagnosed from 1990 to 1994 in 22 European countries and showed that 5-year survival rates were highest in men in Estonia (7.0%) and in women in Czech Republic (7.5%), while lowest survival rates were recorded in men in Malta (0.0%) and in women in Slovenia (1.3%)[37]. Survival from pancreatic cancer in Germany in the early 21st century was 9.0%[35].

Survival rates of pancreatic cancer in population are affected by many factors, such as the type of cancer, the staging at the time of diagnosis, serum albumin level, and tumor size, treatment modality, availability and differences in health care systems, and other factors including age, sex, overall health, lifestyle[23,37,41-50]. Besides, pancreatic cancer survival rates could be influenced by factors such as the validity of cancer registry, exhaustiveness and quality of registration data, completeness of follow-up[22,51].

ETIOLOGY AND RISK FACTORS

To date, the causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified. People are at higher risk to develop pancreatic cancer with any of the risk factors such as smoking, obesity, genetics, diabetes, diet, inactivity[9,12,13,52].

In the study in the United Kingdom in 2011 it was estimated that around 26.2% of pancreatic cancers in men and 31.0% in women was linked to tobacco smoking[9]. The International Agency for Research on Cancer confirmed that smoking is causally associated with pancreatic cancer[11,33]. A recent meta-analysis that included 82 studies found that the risk of pancreatic cancer was RR = 1.7 for current and RR = 1.2 for former smokers[53,54]. Cigarette smoking causes an increase in the risk of pancreatic cancer by 75 percent compared to non-smokers, and the risk persists for at least 10 years after smoking cessation[34,54]. The European (EPIC) study showed in 2012 that risk increased for every five cigarettes smoked per day[55]. Also, the same EPIC study noticed that passive smoking can increase the risk of pancreatic cancer by 50%[54].

The risk of developing pancreatic cancer increases with age[13,56]. Over 80% of pancreatic cancers develop between the ages of 60 and 80 years. Pancreatic cancer rarely occurs before the age of 40, and more than half of cases of pancreatic adenocarcinoma occur in those over 70. Pancreatic cancer affects men and women equally[1,56]. Studies in the United States have shown that pancreatic cancer is more common in the African American population than it is in the white population[57,58]. Some of this increased risk may be due to socioeconomic factors and to cigarette smoking[3,24,53,56].

According to an American Cancer Society study, obesity has been associated with increased mortality from cancer of the pancreas: risk of pancreatic cancer among obese (body mass index BMI ≥ 30) men and women compared with men and women of normal body mass index (< 25) was RR = 2.08[59]. A burden study published in 2011 estimated that, in the United Kingdom, around 12.8% of pancreatic cancers in men and 11.5% in women can attributed to overweight/obesity[9]. The recent meta-analysis has confirmed the hypothesis that both general and abdominal obesity are associated with increased pancreatic cancer risk[60]. Besides, physical inactivity has been linked with increased risk of cancer of the pancreas.

There is some evidence that intake of red or processed meat and high-temperature cooking may increase the risk of pancreatic cancer. In a large United Kingdom cohort study in 2016, low meat eaters (about 30%-45% lower mortality), as well as vegetarians and vegans (about 50% lower mortality) had lower mortality for pancreatic cancer compared with regular meat eaters[61]. The EPIC study found no association between intakes of red and processed meat and pancreatic cancer risk, while poultry consumption was associated with an increased risk[62]. A recent meta-analysis of 11 prospective studies found a positive association between pancreatic cancer incidence and processed meat consumption[63]. But, some studies have not supported these findings[64], or have provided support for the association among men only[65]. On the other hand, frequent nut consumption is inversely associated with risk of pancreatic cancer in women[66,67]. A recent large nested case-control study in 2010 showed increased risk even at consumption of 60 g/d or more of liquor (spirits), and found no association with beer or wine[68]. Findings from the latest meta-analysis support that fruit and vegetable intake is associated inversely with the risk of pancreatic cancer[69]. Additionally, a summary review of meta-analytical studies showed that the major protective factor is increasing fruit or folate intake, with respective population preventable fractions of 0-12%[70]. In the Italian population, 11.9% of pancreatic cancers were attributable to a low adherence to Mediterranean diet[71].

Diabetes mellitus is linked with increased risk of pancreatic tumors[70,72]. Both type I and type II diabetes have doubled the risk of pancreatic cancer[72-74]. The pancreatic cancer burden study in the Italian population estimated that 9.7% of pancreatic cancers were attributable to diabetes[71]. The United States National Cancer Institute estimates that diabetes is associated with a 1.8-fold increased risk of pancreatic cancer, particularly in Hispanic men and Asians in comparison with whites and blacks[75]. Pancreatic cancer risk decreased with duration of diabetes, but a 30% excess risk persists for more than two decades after diabetes diagnosis[76]. Oral antidiabetics or insulin use were associated with a reduced risk of pancreatic cancer[75,76].

Some studies showed that Helicobacter pylori (H. pylori) infection is the major risk factors associated with pancreatic cancer, with estimated population attributable fraction of 4%-25%[70]. But, other studies did not observe an association of H. pylori infection with pancreatic cancer[77].

Patients with pancreatitis, especially the chronic or recurrent forms, had a moderate excess of pancreatic cancer risk[78]. About 4% of chronic pancreatitis patients developed pancreatic cancer[79]. It is estimated that 1.34% of pancreatic cancers are atributable to chronic pancreatitis, but for those who were under the age of 65 that risk was two times higher[80]. Patients with hereditary pancreatitis (rare, autosomal-dominant disease, usually occurs at a young age) have a risk that is 50-60 times greater than expected[81].

It is estimated that 5%-10% of pancreatic cancers are hereditary[9,52]. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer[82]. People with at least two first-degree relatives (mother, father, brother, sister) with pancreatic cancer have almost double the risk of people without pancreatic cancer in their family[83].

There are many of inherited genetic disorders which are known to increase the risk for pancreatic cancer, including Lynch syndrome, Peutz-Jeghers syndrome, the Familial atypical multiple mole melanoma syndrome, Hereditary breast and ovarian cancer syndrome, Li-Fraumeni syndrome, Familial adenomatous polyposis, etc[83]. Individuals with mutations or deletion in such genes as PRSS1, K-ras, p16, p53, and BRCA2 have an increased risk of developing pancreatic cancer[84].

Some findings show a link between pancreatic cancer and previous cancers (cancer of the gallbladder, lung, stomach, uterus, breast, colon, etc.) and other conditions (Crohn’s disease, gastric ulcer)[84-86].

Other potential risk factors include aspirin use, occupational exposure to certain pesticides, and dietary factors such as carbohydrate or sugar intake[70,86]. Most of pancreatic cancer risk factors are only weakly associated with the disease. Additionally, many people with pancreatic cancer do not have any one specific risk factor for it.

PREVENTION

There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance. A better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease. Potentially modifiable risk factors include tobacco smoking, obesity, and diabetes mellitus, diet, alcohol consumption. So far, the best preventive strategy against pancreatic cancer is risk reduction, including lifestyle modification (smoking cessation, healthy weight, diet high in fruits and vegetables, regular exercises), and regular control of health issues[9,13,52,53].

Lifestyle modifications

Control of smoking offers the best available strategy for reducing the incidence of pancreatic cancer. It has been estimated that about 30% of pancreatic cancers could be prevented by prevention of smoking[9]. A European-wide prospective study in 2009 showed that risk is reduced to the levels of a non-smoker after just five years of cessation[54].

Epidemiological data show that dietary factors which are associated with increased risk of pancreatic cancer are meat, red meat in particular, and energy: preventive measures include recommendations for reducing the intake. Protection is mainly provided by means of a “prudent”, well balanced diet, diet containing ample fruits and vegetables, nut consumption, vitamins (β-carotene, vitamin D and E), and more dietary compounds[26,87,88]. Also, it is necessary to limit the alcohol use, which is known to increase the pancreatic cancer risk through development of chronic pancreatitis and cirrhosis[89].

Chemoprevention, with agents such as COX inhibitors and aspirin, could mean benefit for persons at high risk for pancreatic cancer and needs to be verified in future[90,91].

Chronic pancreatitis caused by heavy alcohol consumption or by an underlying inherited disorder is associated with a high risk of pancreatic cancer. Reduced alcohol use has been shown to reduce the risk of pancreatic cancer. Screening PRSS1 (Cationic trypsinogen gene) mutation as the mutation that causes hereditary pancreatitis is being performed for the development of a screening programme aimed at detecting pancreatic cancer at an early stage[92].

Patients with cystic neoplasms of the pancreas develop pancreatic cancer in about 60% to 70% of patients[93]. The complete extirpation of cystic neoplasms is now performed as a cancer preventive strategy[94].

Some risk factors such as age, gender, race, and family history cannot be modified. But, there is secondary prevention that might lower pancreatic cancer risk.

Screening and early detection

There is no reliable screening test currently available to screen the general population and detect pancreatic cancer early[95,96]. The research into the area of screening for pancreatic cancer has increased significantly in the past decade. Several screening tests were investigated to aid in the identification or earlier diagnosis of pancreatic cancer for the general population, including the blood markers for pancreatic cancer CA19-9, SPAN-1, CA-50, DUPAN-2, cell surface associated mucins (MUC), carcinoembryonic antigen, and heat shock proteins[10,97]. But these tests have not been well studied yet[98].

Although there are no screening tests currently available to screen the general population, researchers are working on developing effective screening tests that may be applied to groups of persons which have an increased risk of developing pancreatic cancer (such as persons with family history of pancreatic cancer, with abnormalities in certain genes - such as BRCA2, p16, HNPCC, and with histories of familial pancreatitis and Peutz-Jeghers syndrome, etc.)[98,99]. Also, question is which access points (stool, pancreatic juice, saliva and blood) could be appropriate to study these potential screening markers. For persons with high risk of pancreatic cancer (including patients with hereditary pancreatitis or for persons with family members with pancreatic cancer), some screening techniques (i.e., endoscopic ultrasound and spiral computerized tomography) are promising but have not been fully evaluated[100]. In patients with hereditary pancreatitis (in PRSS1 mutation carriers) who have a higher risk of early onset of pancreatic cancer, screening can begin at age 40[92]. There is no consensus about when is screening initiating recommended for other persons. However, it remains an area of great interest[101].

CONCLUSION

Around the world significant efforts are being made in order to better understand pancreatic cancer. Detailed epidemiological analyses of pancreatic cancer trends and further analytical epidemiological researches will help guide future cancer control strategies.

Footnotes

Manuscript source: Invited manuscript

Specialty type: Gastroenterology and hepatology

Country of origin: Serbia

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