Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9694
Peer-review started: July 4, 2016
First decision: August 19, 2016
Revised: August 30, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 28, 2016
Core tip: Pancreatic cancer is the one of leading causes of cancer mortality and one of the most lethal malignant neoplasms across the world. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. The estimated 5-year survival rate for pancreatic cancer is about 5%. The causes of pancreatic cancer are still insufficiently known, although certain risk factors have been identified, such as cigarette smoking, positive family history and genetics, diabetes mellitus, obesity, dietary factors, alcohol use, physical inactivity. There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance.