Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
Peer-review started: March 22, 2016
First decision: May 12, 2016
Revised: May 16, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: July 7, 2016
Core tip: Colorectal cancer (CRC) is one of the most common leading causes of cancer death in the world; therefore, any attempt in early diagnosis, selection of appropriate therapeutic strategies and efficient follow up can play an important role in reducing the disease related mortalities. Our review highlights the novel trends and approaches in CRC biomarker discovery, which are categorized as pathologic genetic or epigenetic changes within the tumor tissue as well as non-invasive biomarkers such as blood or stool based markers. These biomarkers could be used for the management of cancer patients.