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Open-Access Journal
Editorial
From blood to breath: New horizons for esophageal cancer biomarkers 
Roger Yazbeck, Simone E Jaenisch, David I Watson 
World J Gastroenterol 22(46):10077-10083. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10077
Review
Can probiotics benefit children with autism spectrum disorders? 
Fernando Navarro, Yuying Liu, Jon Marc Rhoads 
World J Gastroenterol 22(46):10093-10102. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10093
Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective 
Jordan E Axelrad, Abhik Roy, Garrett Lawlor, Burton Korelitz, Simon Lichtiger 
World J Gastroenterol 22(46):10103-10117. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10103
Minireviews
Role of dupA in virulence of Helicobacter pylori 
Amin Talebi Bezmin Abadi, Guillermo Perez-Perez 
World J Gastroenterol 22(46):10118-10123. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10118
Dilemma of first line regimens in metastatic pancreatic adenocarcinoma 
Marwan Ghosn, Tony Ibrahim, Tarek Assi, Elie El Rassy, Hampig Raphael Kourie, Joseph Kattan 
World J Gastroenterol 22(46):10124-10130. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10124
Basic Study
Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus 
Kyung Sik Park, Kwang Bum Cho, Il Seon Hwang, Jae Hyung Park, Byung Ik Jang, Kyeong Ok Kim, Sung Woo Jeon, Eun Soo Kim, Chang Sik Park, Joong Goo Kwon 
World J Gastroenterol 22(46):10131-10139. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10131
Correlation between colonic secretion and colonic motility in rats: Role of ghrelin 
Hsien-Hao Huang, Ching-Heng Ting, Yu-Fong Syu, Shi-Chuan Chang, Chih-Yen Chen 
World J Gastroenterol 22(46):10140-10147. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10140
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure 
Yan-Chang Lei, Chun-Lei Lu, Ling Chen, Ke Ge, Ling-Ling Yang, Wen Li, Yuan-Hua Wu 
World J Gastroenterol 22(46):10148-10157. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10148
NADPH oxidase-1 deficiency offers little protection in Salmonella typhimurium-induced typhlitis in mice 
Fong-Fong Chu, R Steven Esworthy, James H Doroshow, Binghui Shen 
World J Gastroenterol 22(46):10158-10165. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10158
Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis 
Ming-Jun Wang, Wen-Wu Ling, Hong Wang, Ling-Wei Meng, He Cai, Bing Peng 
World J Gastroenterol 22(46):10166-10179. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10166
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat 
Wei Jiang, Mei-Hua Guo, Xin Hai 
World J Gastroenterol 22(46):10180-10188. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10180
Case Control Study
Use of a saline-coupled bipolar sealer open liver resection for hepatic malignancy: Medical resource use and costs 
Christine I Nichols, Joshua G Vose 
World J Gastroenterol 22(46):10189-10197. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10189
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome? 
Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini 
World J Gastroenterol 22(46):10198-10209. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10198
Effect of switching from treatment with nucleos(t)ide analogs to pegylated interferon α-2a on virological and serological responses in chronic hepatitis B patients 
Li-Ting He, Xiao-Guang Ye, Xiao-Yuan Zhou 
World J Gastroenterol 22(46):10210-10218. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10210
Retrospective Study
Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study 
Marcelo Campos Appel-da-Silva, Suelen Aparecida da Silva Miozzo, Isabella de Azevedo Dossin, Cristiane Valle Tovo, Fernanda Branco, Angelo Alves de Mattos 
World J Gastroenterol 22(46):10219-10225. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10219
Prospective Study
Genotype specific peripheral lipid profile changes with hepatitis C therapy 
Mark R Pedersen, Amit Patel, David Backstedt, Myunghan Choi, Anil B Seetharam 
World J Gastroenterol 22(46):10226-10231. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10226
Long-term prognostic impact of circulating tumour cells in gastric cancer patients 
Hiroaki Ito, Jun Sato, Yukio Tsujino, Noriko Yamaguchi, Satoshi Kimura, Keigo Gohda, Katsuhiro Murakami, Manabu Onimaru, Tohru Ohmori, Fumihiro Ishikawa, Haruhiro Inoue 
World J Gastroenterol 22(46):10232-10241. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10232
Randomized Controlled Trial
Randomized controlled study of the safety and efficacy of nitrous oxide-sedated endoscopic ultrasound-guided fine needle aspiration for digestive tract diseases 
Cai-Xia Wang, Jian Wang, Yuan-Yuan Chen, Jia-Ni Wang, Xin Yu, Feng Yang, Si-Yu Sun 
World J Gastroenterol 22(46):10242-10248. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10242
Case Report
En bloc” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer 
Patricia Sánchez-Velázquez, Nicolas Moosmann, Ingolf Töpel, Pompiliu Piso 
World J Gastroenterol 22(46):10249-10253. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10249
Response of BRCA1-mutated gallbladder cancer to olaparib: A case report 
Yuan Xie, Yan Jiang, Xiao-Bo Yang, An-Qiang Wang, Yong-Chang Zheng, Xue-Shuai Wan, Xin-Ting Sang, Kai Wang, Da-Dong Zhang, Jia-Jia Xu, Fu-Gen Li, Hai-Tao Zhao 
World J Gastroenterol 22(46):10254-10259. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10254
Schwannoma in the hepatoduodenal ligament: A case report and literature review 
Shao-Yan Xu, Ke Sun, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng, Wei-Lin Wang 
World J Gastroenterol 22(46):10260-10266. Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10260