Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective

doi:10.3748/wjg.v22.i46.10103

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Dec 14, 2016 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2016; 22(46): 10103-10117
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10103

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Figure 1 Chemical structures of azathioprine and mercaptopurine. AZA: Azathioprine; 6-MP: 6-mercaptopurine.

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Figure 2 Metabolic pathway for azathioprine and mercaptopurine. AZA: Azathioprine; 6-MP: 6-mercaptopurine; 6-TU: Thiouric acid; 6-MMP: 6-methylmercaptopurine; 6-TIMP: 6-thioinosine-monophosphate; 6-MMPR: Methyl-mercaptopurine ribonucleotide; 6-TGN: Thioguanine nucleotide; XO: Xanthine oxidase; TPMT: Thiopurine methyltransferase; HPRT: Hypoxanthine phosphoribosyl transferase; IMPDH: Inosine monophosphate dehydrogenase; GMPS: Guanosine monophosphate synthetase.

Citation: Axelrad JE, Roy A, Lawlor G, Korelitz B, Lichtiger S. Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective. World J Gastroenterol 2016; 22(46): 10103-10117
URL: https://www.wjgnet.com/1007-9327/full/v22/i46/10103.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i46.10103