Yuan Xie, Xiao-Bo Yang, An-Qiang Wang, Yong-Chang Zheng, Xue-Shuai Wan, Xin-Ting Sang, Hai-Tao Zhao, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Yan Jiang, Da-Dong Zhang, Jia-Jia Xu, Fu-Gen Li, Institute of Precision Medicine, 3D Medicines Inc, Shanghai 201114, China
Kai Wang, Center for Precision Medicine, Zhejiang University International Hospital, Hangzhou 310000, Zhejiang Province, China
Author contributions: Xie Y and Jiang Y contributed equally to this work; Yang XB, Wang AQ, Zheng YC, Wan XS followed up the patient; Wang K, Zhang DD, Xu JJ provided genetic analysis for the variants tested in the patient; Li FG analyzed the genetic data and revised the manuscript; Sang XT and Zhao HT provided financial support for this work; Xie Y and Jiang Y wrote the paper; all authors have read and approved the final manuscript.
Supported by International Science and Technology Cooperation Projects, No. 2015DFA30650 and No. 2010DFB33720; Capital Special Research Project for Health Development, No. 2014-2-4012; and Capital Research Project for the Characteristics Clinical Application, No. Z151100004015170.
Institutional review board statement: The publication of this manuscript has been reviewed and approved by the PUMCH institutional review board.
Informed consent statement: The patient and his family signed informed consent before gene test and drug treatment.
Conflict-of-interest statement: We declare that the authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hai-Tao Zhao, MD, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. email@example.com
Telephone: +86-10-69156042 Fax: +86-10-69156042
Received: July 31, 2016
Peer-review started: August 1, 2016
First decision: August 19, 2016
Revised: September 1, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: December 14, 2016