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World J Gastroenterol. Dec 14, 2016; 22(46): 10118-10123
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10118
Role of dupA in virulence of Helicobacter pylori
Amin Talebi Bezmin Abadi, Guillermo Perez-Perez
Amin Talebi Bezmin Abadi, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran
Guillermo Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine and VA Medical Center, New York, NY 10010, United States
Author contributions: Talebi Bezmin Abadi A and Perez-Perez G prepared the first draft and finalized it for publication.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amin Talebi Bezmin Abadi, PhD, Assistant Professor, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran. amin.talebi@modares.ac.ir
Telephone: +98-21-82884883 Fax: +98-21-82884883
Received: August 23, 2016
Peer-review started: August 24, 2016
First decision: September 12, 2016
Revised: September 27, 2016
Accepted: November 14, 2016
Article in press: November 16, 2016
Published online: December 14, 2016
Core Tip

Core tip: Helicobacter pylori (H. pylori) is one of the most common bacterial infections worldwide. Ten years ago, virB4 homologue was identified as a new virulence factor, dupA “duodenal ulcer promoting gene A” by Lu and her colleagues. Nowadays, new genetical analysis using available sequences can help scientists to draw a better conclusion about dupA and its actual role in pathogenesis of H. pylori-related diseases. In this paper, we aim to draw a new shaped overview regarding H. pylori and its virulence factors with emphasis of dupA.