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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2016; 22(46): 10124-10130
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10124
Dilemma of first line regimens in metastatic pancreatic adenocarcinoma
Marwan Ghosn, Tony Ibrahim, Tarek Assi, Elie El Rassy, Hampig Raphael Kourie, Joseph Kattan
Marwan Ghosn, Tony Ibrahim, Tarek Assi, Elie El Rassy, Hampig Raphael Kourie, Joseph Kattan, Department of Oncology, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon
Author contributions: Kattan J initiated the review; Ghosn M, Ibrahim T and Assi T performed the review, analyzed the data and wrote first draft; Ghosn M, El Rassy E, Kourie HR and Kattan J, reviewed and commented on the paper; all authors provided final approval for the content.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marwan Ghosn, MD, Department of Oncology, Faculty of Medicine, Saint Joseph University, Alfred Naccache, Beirut 166830, Lebanon. marwanghosnmd@yahoo.com
Telephone: +961-3-226842 Fax: +961-1-613397
Received: August 21, 2016
Peer-review started: August 25, 2016
First decision: September 5, 2016
Revised: September 23, 2016
Accepted: October 30, 2016
Article in press: October 31, 2016
Published online: December 14, 2016
Core Tip

Core tip: This paper is a mini-review that compares the design of the two pivotal trials studying the role of FOLFIRINOX and gemcitabine/nab-Paclitaxel in the management of metastatic pancreatic cancer. It also analyzes the effects these regimens have on toxicity profile, quality of life, real life experiences, choice of second-line therapy and cost.