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Open-Access Journal
Editorial
Gallbladder carcinoma: Prognostic factors and therapeutic options 
Thorsten Oliver Goetze 
World J Gastroenterol 21(43):12211-12217. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12211
Topic Highlight
Stage migration vs immunology: The lymph node count story in colon cancer 
Bruno Märkl 
World J Gastroenterol 21(43):12218-12233. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12218
Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer 
Ken-ichi Fujita, Yutaro Kubota, Hiroo Ishida, Yasutsuna Sasaki 
World J Gastroenterol 21(43):12234-12248. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12234
Recent aspects for disseminated carcinomatosis of the bone marrow associated with gastric cancer: What has been done for the past, and what will be needed in future? 
Haruo Iguchi 
World J Gastroenterol 21(43):12249-12260. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12249
Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? 
Shikha Satendra Singh, Wei Ney Yap, Frank Arfuso, Shreya Kar, Chao Wang, Wanpei Cai, Arunasalam M Dharmarajan, Gautam Sethi, Alan Prem Kumar 
World J Gastroenterol 21(43):12261-12273. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12261
MicroRNA in inflammatory bowel disease: Translational research and clinical implication 
Kurt Fisher, Jingmei Lin 
World J Gastroenterol 21(43):12274-12282. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12274
Th17 plasticity and its changes associated with inflammatory bowel disease 
Aito Ueno, Abhisek Ghosh, Daniel Hung, Ji Li, Humberto Jijon 
World J Gastroenterol 21(43):12283-12295. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12283
Genetics of inflammatory bowel disease from multifactorial to monogenic forms 
Anna Monica Bianco, Martina Girardelli, Alberto Tommasini 
World J Gastroenterol 21(43):12296-12310. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12296
Role of liver transplantation in human immunodeficiency virus positive patients 
Deepak Joshi, Kosh Agarwal 
World J Gastroenterol 21(43):12311-12321. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12311
Review
Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications 
Francesca Romana Ponziani, Viviana Gerardi, Silvia Pecere, Francesca D’Aversa, Loris Lopetuso, Maria Assunta Zocco, Maurizio Pompili, Antonio Gasbarrini 
World J Gastroenterol 21(43):12322-12333. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12322
Stem cell-based regenerative opportunities for the liver: State of the art and beyond 
Eleftheria Tsolaki, Evangelia Yannaki 
World J Gastroenterol 21(43):12334-12350. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12334
Basic Study
N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats 
Francielli Licks, Renata Minuzzo Hartmann, Camila Marques, Elizângela Schemitt, Josieli Raskopf Colares, Mariana do Couto Soares, Juliana Reys, Camila Fisher, Juliana da Silva, Norma Possa Marroni 
World J Gastroenterol 21(43):12351-12360. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12351
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis 
Fahed Parvaiz, Sobia Manzoor, Jawed Iqbal, Mehuli Sarkar-Dutta, Muhammad Imran, Gulam Waris 
World J Gastroenterol 21(43):12361-12369. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12361
Magnesium isoglycyrrhizinate inhibits inflammatory response through STAT3 pathway to protect remnant liver function 
Guang-Hua Tang, Hua-Yu Yang, Jin-Chun Zhang, Jin-Jun Ren, Xin-Ting Sang, Xin Lu, Shou-Xian Zhong, Yi-Lei Mao 
World J Gastroenterol 21(43):12370-12380. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12370
Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury 
Chen Zhong, Li-Yong Pu, Ming-Ming Fang, Zhen Gu, Jian-Hua Rao, Xue-Hao Wang 
World J Gastroenterol 21(43):12381-12391. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12381
Retrospective Study
Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound 
Wolfgang Kratzer, Beate Gruener, Tanja EM Kaltenbach, Sarina Ansari-Bitzenberger, Peter Kern, Michael Fuchs, Richard A Mason, Thomas FE Barth, Mark M Haenle, Andreas Hillenbrand, Suemeyra Oeztuerk, Tilmann Graeter 
World J Gastroenterol 21(43):12392-12402. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12392
Surgery in (pre)malignant celiac disease 
Jolanda MW van de Water, Petula Nijeboer, Laura R de Baaij, Jessy Zegers, Gerd Bouma, Otto J Visser, Donald L van der Peet, Chris JJ Mulder, Wilhelmus JHJ Meijerink 
World J Gastroenterol 21(43):12403-12409. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12403
Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients 
Anna Song, Wankyu Eo, Sookyung Lee 
World J Gastroenterol 21(43):12410-12420. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12410
Relationship between virological response and FIB-4 index in chronic hepatitis B patients with entecavir therapy 
Ni Li, Jing-Hang Xu, Min Yu, Sa Wang, Chong-Wen Si, Yan-Yan Yu 
World J Gastroenterol 21(43):12421-12429. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12421
Observational Study
Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs 
Joshua Hartman, Kian Bichoupan, Neal Patel, Sweta Chekuri, Alyson Harty, Douglas Dieterich, Ponni Perumalswami, Andrea D Branch 
World J Gastroenterol 21(43):12430-12438. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12430
Combined transjugular intrahepatic portosystemic shunt and other interventions for hepatocellular carcinoma with portal hypertension 
Bin Qiu, Meng-Fei Zhao, Zhen-Dong Yue, Hong-Wei Zhao, Lei Wang, Zhen-Hua Fan, Fu-Liang He, Shan Dai, Jian-Nan Yao, Fu-Quan Liu 
World J Gastroenterol 21(43):12439-12447. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12439
Randomized Clinical Trial
Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis 
Samira M Sadowski, Axel Andres, Philippe Morel, Eduardo Schiffer, Jean-Louis Frossard, Alexandra Platon, Pierre-Alexandre Poletti, Leo Bühler 
World J Gastroenterol 21(43):12448-12456. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12448
Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects 
Masahiro Kikuchi, Yusuke Ushida, Hirokazu Shiozawa, Rumiko Umeda, Kota Tsuruya, Yudai Aoki, Hiroyuki Suganuma, Yasuhiro Nishizaki 
World J Gastroenterol 21(43):12457-12467. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12457
Systematic Reviews
Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature 
Emo E van Halsema, Erik AJ Rauws, Paul Fockens, Jeanin E van Hooft 
World J Gastroenterol 21(43):12468-12481. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12468
Cooperative laparoscopic endoscopic and hybrid laparoscopic surgery for upper gastrointestinal tumors: Current status 
Dimitrios Ntourakis, Georgios Mavrogenis 
World J Gastroenterol 21(43):12482-12497. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12482
Case Report
Intraductal papillary neoplasm of the bile ducts: A case report and literature review 
Yaohong Tan, Clara Milikowski, Yanelba Toribio, Adam Singer, Claudia P Rojas, Monica T Garcia-Buitrago 
World J Gastroenterol 21(43):12498-12504. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12498
Cholestasis, ascites and pancytopenia in an immunocompetent adult with severe cytomegalovirus hepatitis 
Jun-Yan Qian, Xiao-Yin Bai, Yun-Lu Feng, Wen-Jia Zhu, Fang Yao, Jing-Nan Li, Ai-Ming Yang, Fang Li, Jia-Ming Qian 
World J Gastroenterol 21(43):12505-12509. Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12505
Letters To The Editor